Transport of O2 and CO2 in blood

Question 1

In solution, only _____ gas molecules generate the partial pressure

Answer 1

dissolved

Question 2

Methemoglobin

Answer 2

hemoglobin variant, iron is in Fe+++ state

does not bind O2

Question 3

What are some things that can cause methemoglobin

Answer 3

nitrites and sulfonamides

deficiency of methemoglobin reductase

Question 4

What is the O2 binding capacity

Answer 4

the maximum O2 volume that can combine with Hb

depends on Hb concentration and binding procperties

Question 5

What is the O2 content

Answer 5

actual amount of O2 per volume of blood

Question 6

What is the equation for O2 content

Answer 6

O2 binding capacity x SaO2 +dissolved O2

Question 7

What is the SaO2

Answer 7

% of heme groups bounds to O2

Question 8

How do you calculate O2 delivery

Answer 8

CO x oxygen content

Question 9

What are some factors that affect tissue oxygen delivery

Answer 9

CO in 3rd degree heart failture
hemogoblin in anemia
decreased RBC production in chronic kidney failure

Question 10

What is the normal shape of the O2-Hb dissociation curve?

Answer 10

sigmoidal

Question 11

What is the flat upper part of the O2-Hb dissociation curve

Answer 11

ensures constant oxyhemoglobin saturation for aterial blood despite wide variations in O pressure

Question 12

What is the steep lower part of the O2-Hb dissociation curve

Answer 12

considerable amounts of O can be unloaded to peripheral tissues with only a small drop in capillary PO2

Question 13

Under normal conditions about ______ of oxygen are transported from lungs to tissues by each 100 mL of blood flow

Answer 13

5 mL

Question 14

Hb automatically delivers O2 to tissues at _________

Answer 14

a tight PO2 range

Question 15

What does an increase in P50 mean

Answer 15

weaker binding

Oxygen gets released more easily

Question 16

What does a decrease in P50 mean

Answer 16

tighter binding

Oxygen wants to stay bound

Question 17

How does fever affect Hb-O2 binding

Answer 17

right shift,

O2 gets released more easily

Question 18

How does hypothermia affect Hb-O2 binding

Answer 18

left shift

O2 wants to stay bound

Question 19

How does decreasing pH affect Hb-O2 binding

Answer 19

right sift

O2 gets released more easily (bohr effect)

Question 20

How does increasing pH affect Hb-O2 binding

Answer 20

left shift

O2 wants to stay bound

Question 21

How does 2,3 DOG affect Hb-O2 binding

Answer 21

right shift

O2 gets released more easily

Question 22

What are the symptoms of CO poisoning

Answer 22

altered reaction time
blurred vision
unconsciousness

Question 23

What is the main form of CO2 transport in the body

Answer 23

bicarb in RBCs

Question 24

7% of CO2 is in what form

Answer 24

dissolved

Question 25

23% of CO2 is in what form

Answer 25

conjugated with Hb

Question 26

What is the Haldane effect

Answer 26

higher PO2 will shift CO2 equilibrium curve down and right, allows blood to load more CO2 into tissues, and unload more CO2 in lungs