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Immunology > Transplant and Lab > Flashcards

Transplant and Lab Flashcards

1
Q

Direct Coombs tests:

A

Anti-Rh Ab bound to infant RBC

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2
Q

Hyperacute rejection mechanism and Pathogenesis

A

Complement activation, endothelial damage, inflammation and thrombosis

Alloantigen and Circulating alloantigen specific Ab

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3
Q

Acute rejection mechanism and pathogenesis

A

Parenchymal cell damage, interstitial inflammation

Endothelialitis

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4
Q

Graft-vs-Host disease

A

When any mature T cell remaining in the BM can attack allogeneic MHC-bearing cells of the recipient and cause widespread epithelial cell death

Rash, Jaundice, diarrhea, and GI Hemorrhage

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5
Q

Isograft

A

Transplanted between genetically identical individuals

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6
Q

Latex bead agglutination is used to Dx:

A

Cerebrospinal infections of:

  1. Haemophilus
  2. Pneumococcus
  3. Meningococcus
  4. Cryptococcus neoformans
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7
Q

What increases the expression of MHC 2 on graft

A

IFN-γ

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8
Q

Xenogeneic graft

A

Between members of different species

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9
Q

Routine HLA Typing focuses on

A

HLA-A

HLA-B

HLA-DR

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10
Q

Fluorescent Ab Tests used to Dx:

A
  1. RSV
  2. Herpes 1 and 2
  3. Pneumocystis
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11
Q

Indirect fluorescent antibody test identfies

A

Abs in the pt

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12
Q

Autograph

A

Tissue is moved from one location to another in the same individual

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13
Q

Chronic rejection mechanism and pathogenesis

A

Chronic DTH reaction in vessel wall

Intimal smooth muscle cell proliferation

vessel occlusion

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14
Q

Indirect Coombs tests:

A

Used to identify Rh-negative mother who are producing anti-Rh Ab of the IgG isotype

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15
Q

Allogeneic graft

A

between genetically different members of the same species

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16
Q

Indirect Fluorescent Ab test used for

A
  1. Anti-nuclear Ab
  2. Anti-dsDNA Ab
  3. Antithyroid Ab
  4. Antiglomerular BM Ab
  5. Anti-EBV viral capsid antigen Ab
17
Q

Direct fluorescent antibody test identifies

A

Ag in tissues

18
Q

What increases the expression of MHC 1 in the graft

A

TNF-α

TNF-β

Interferons

Immunology (11 decks)

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