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Immunology > Cells of Immune System > Flashcards

Cells of Immune System Flashcards

1
Q

V, D, and J are combined to make

A
  • Variable domain of B-cell heavy chain
  • Variable domain of T-cell β chain
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2
Q

TCR is designed to bind to

A

Only cell-bound peptides

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3
Q

SCID Genetics

A

AR

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4
Q

B-Cell identification

A
  • CD 19
  • CD 20
  • CD 21
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5
Q

SCID molecular defect

A

Null mutation in rag1 or rag2 gene causing NO rag enzyme

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6
Q

Basophil function

A
  • NONPHAGOCYTIC
  • Release pharmacologically active substances during allergic response
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7
Q

Macrophage function

A
  • Phagocytosis
  • Secretion of cytokines
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8
Q

Eosinophil function

A

Kill AB coated parasites

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9
Q

Omenn Syndrome molecular defect

A

Missense mutation in rag gene

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10
Q

What enzyme randomly inserts bases at the junctions of V, D, and J segments?

A

Terminal Deoxyribonucleotidyl transferase (Tdt)

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11
Q

Eosinophil identifiction

A
  • Bilobed nucleus
  • Large pink granules
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12
Q

Tdt is used for

A

a marker for early stage T-cell and B-cell development in ALL

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13
Q

Monocyte function

A
  1. Phagocytic
  2. Differentiate into tissue Macrophages
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14
Q

Allelic exclusion is

A

Once a functional product has been achieved by rearrangement, the cell shuts off rearrangement and expression of the other allele on the homologous chromosome

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15
Q

T progenitor becomes T cell in

A

Thymus

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16
Q

Megakaryocyte to platelets require

A

IL-11

17
Q

Monocyte Identification

A

Kidney-bean-shaped nucleus

CD 14

18
Q

NK Cells identification

A
  • CD 16
  • CD 56
19
Q

Omenn Syndrome Symptoms

A
  1. Lack of B-Cells
  2. Decrease in T-Cells
  3. Early onset failure to thrive
  4. Red Rash (generlized)
  5. Diarrhea
  6. Severy Immune deficiency
20
Q

Pluripotent stem cell to Lymphoid stem cell requires

A

IL-7

21
Q

Pluripotent stem cell to Myeloid stem cell requires

A
  • GM-CSF
  • IL-3
22
Q

Basophil identifiction

A
  • Bilobed nucleus
  • Large blue granules
23
Q

Myeloid stem cell to Eosinophil requires

A

IL-5

24
Q

Idiotype of IG is

A

in the N-terminal pocket of heavy and light chain that is unique to a certain antigen

25
Q

Constant domain consists of

A

κ and λ

26
Q

Neutrophil identifiction

A
  • Multilobed nucleus
  • Small light pink to purple granules
27
Q

V and J rearrangement makes

A

Variable domain AA of the light chain

28
Q

Isotype of IG is

A

Determined by domains towards C-terminus and is the classes of IG

29
Q

Macrophage identification

A
  • Ruffled membrane
  • Cytoplasm with vacuoles and vesicles
  • CD 14
30
Q

Omenn Sydrome genetics

A

AR

Immunology (11 decks)

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