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HS and Autoimmune Flashcards

1
Q

Acute Rheumatic Fever Target antigen

A

Type 2 HS

Strep cell-wall Ag

Ab cross-reacts with myocardial AG

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2
Q

Reiter’s Syndrome HLA allele

A

B27

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3
Q

Guillain-Barre Syndrome specific pathogenic T cells

A

Peripheral nerve myelin or gangliosides

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4
Q

SLE antigen involved

A

Type 3 HS

dsDNA

Sm

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5
Q

Mast cell Mediators that are stored and released in response to Type 1 HS

A
  1. Histamine
  2. Heparin
  3. Eosinophil Chemotactic factor A
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6
Q

MS HLA allele

A

DR2

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7
Q

Type 1 HS Tissue injury mechanism

A

Mast cells and their mediators

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8
Q

Graves Disease HLA allele

A

B8

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9
Q

Inflammatory Bowel Disease HLA allele

A

B27

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10
Q

Ankylosing spondylitis HLA allele

A

B27

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11
Q

Type 4 HS examples

A
  1. MS
  2. Hashimoto
  3. RA
  4. IDDM
  5. Guillain-Barre (Ascending paralysis, peripheral nerve demyelination)
  6. Celiac
  7. Crohn
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12
Q

Celiac HLA allele

A

DQ2 or DQ8

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13
Q

Type 3 HS immune mechanism

A

Immune Complex Mediated

Immune complexes of circulating Ags and IgM or IgG Abs

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14
Q

Psoriasis HLA allele

A

B27

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15
Q

IDDM HLA allele

A

DR3/DR4

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16
Q

Type 4 HS immune mechanism

A
  1. CD4 TH1 and TH17 cells and their Cytokines
  2. Cells of CMI that are stimulated
17
Q

Type 1 HS immune mechanism

18
Q

Rheumatoid Arthritis HLA allele

19
Q

Mast cell Mediators that are newly synthesized from Arachidonic acid in response to Type 1 HS

A
  1. PGD2
  2. PGE2
  3. PGF2α
  4. Leukotrienes C4, D4, E4
  5. Leukotriene B4
20
Q

SLE clinical manifestations

A
  1. Nephritis
  2. Arthritis
  3. Vasculitis
  4. Butterfly Facial Rash
21
Q

Goodpasture’s HLA allele

22
Q

PSGN clinical manifestations

A

Nephritis

Lumpy-Bumpy deposits

23
Q

PSGN antigen involved

A

Type 3 HS

Strep cell wall Ags

24
Q

Type 2 HS immune mechanism

A

Antibody-mediated

IgM and IgG Abs against cell or tissue Ags

25
Q

SLE HLA allele

26
Q

Effector cells of Type 1 HS

A

Mast cells

Basophils

Eosinophils

27
Q

Automimmune hemolytic anemia mechanism of pathogenesis

A
  • Opsonization
  • Phagocytosis
  • Complement-mediated destruction of RBC
28
Q

Graves disease Target antigen

A

Type 2 HS

TSH receptor

29
Q

Autoimmune Helolytic Anemia Target Antigen

A

Type 2 HS

RBC membrane protein

30
Q

Prostaglandin effects

A

Increased smooth muscle contraction and vascular permeability

31
Q

Myasthenia gravis target antigen

A

Type 2 HS

Ach receptor

32
Q

Histamine effect

A
  • Smooth muscle contraction (Bronchoconstriction, Intestinal hypermotility)
  • Increased Vascular permeability
33
Q

Goodpasture Syndrome Target antigen

A

Type 2 HS

Type 4 collagen in BM of kidney glomeruli and lung alveoli

Immunology (11 decks)

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