Transplant

Question 1

what is the most accurate way to measure GFR for a potential living kidney donor

Answer 1

MAG-3 renal scan

Question 2

UNOS criteria for liver transplantation for HCC

Answer 2

• single lesion < 5 cm
  OR
• 3 lesions, with none larger than 3 cm

This is also known as the Milan Criteria

Question 3

most common cause of diarrhea in liver transplant patients

Answer 3

Mycophenolate mofetil (drug side effect)

Question 4

Tacrolimus mechanism of action

Answer 4

FK506 binding protein

inhibits calcineurin and its downstream Tcell activation pathways

Question 5

Adverse side effects of Tacrolimus

Answer 5

Neurotoxicity
Nephrotoxicity
Hyperglycemia

Question 6

Patient with a recent transplant presents with seizures, AKI and high blood glucose levels, what drug could account for these?

Answer 6

Tacrolimus

Question 7

pt s/p renal transplant presents with cauliflower like growths in the perianal region

• management for minimal disease
• management for extensive disease

Answer 7

• topical pohophyllin resin in benzoin solution
• Excision of lesions

Question 8

Most common malignancy in Transplant patients

Answer 8

Squamous cell Carcinoma

Question 9

How would you treat CMV infection in a transplant patient

Answer 9

1. decrease immunosuppression
2. treat with either PO Valgancyclovir or IV gancyclovir