transplant Flashcards
non depleting ab’s
bind to IL -2 receptors on activated T cells such as daclizumab and basiliximab
post transplant lymphoproliferative disorder
Causes the lymphocytes to multiply out of control can range from beingn to lymphomas
calcineurin inhibitors example and function
cyclosporin, tacrolimus they prevent the activiation of t cells
adrs of calcinueuring inhibiots
hirtism, hypertension, nephrotixic( acute+chronic), gum hypertrophy, glucose intolerance
inhibitors of purine sythesis example and adr
Azathioprine and leukopenia
what’s definition of chronic rejection and what are the features
> 6 months and associated with interstitial fibrosis and tubular atrophy, its difficult to manage as its not responsive to immunotherapy
post transplant malignancy is mainly located where
skin ( scc, bcc,) and anogenital cancers
induction is with
IL2
maintenance
CNI tacrilimus 1st line + anti proliferative agents such as MMF
usually triple therapy inc CS
indication for transplant
ESRD GFR < 15
which is the best kidney transplant option to use
living donor, as the least time the kidney has been exposed to schema . Age of donor is the best predictor of outcome
types of allograft rejection
- T cell mediated rejection- acute tubiliits
- antibody (with or without T cell)
how to treat an acute reaction
high does of methylprednioslone
main mechanism of acute rejection
cell mediated
most common type of reaction
ACUTE - months (type 4 ) delayed
