lupus and diabetes Flashcards

1
Q

how many classifications of lupus

A

6

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2
Q

onset of lupus

A

15-45

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3
Q

how many criteria and how many to fill

A

4/11 to fill

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4
Q

do patients have nephritic or nephrotic proteinuria

A

can be both, initially nephritic then progresses to nephrotic usually or can skip straight to nephrotic

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5
Q

name the different stages

A
  1. minimal mesangial
  2. mesangial proliferative
  3. focal
  4. diffuse
  5. membranous
  6. advanced sclerosis
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6
Q

which is the worst class of lupus

A

diffuse lupus

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7
Q

what deposition is lupus mainly associated with

A

subendothelial deposition

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8
Q

which deposit will give you significant proteinuria

A

subepithelial because now its close to the BM

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9
Q

treament of lupus nephritis hypertension

A

ACE + ARBS

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10
Q

what drug is solu-medol

A

methylprednisolone

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11
Q

what antibodies/subsances can be seen on staining and which is the most common

A

IG G most common but iG M + IG A can ve seen and c3 and c1q

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12
Q

some of the factors involved in diabetic neprhopathy

A
IGF 
VEFG
TGF- b1 
thrombospondin 
AGE - advanced glycation end products
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13
Q

hall mark findings in diabetes

A

mesangial expansion
nodules- kimmelstein
glomerulosclerosis

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14
Q

which has a wire looping appearance

A

diffuse proliferative GN= lupus nephritis, sunednoehtlial deposits and you see a GRANULAR PATTERN

LM:neurtiphil and hyaline thrombi

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15
Q

what will you see on lM in class 4 lupus

A

hyaline thrombi and neutrophils

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16
Q

antibodies

A

double stranded DNA

anti- sm - very specific but not found in all patients

17
Q

which parts of the kidney does lupus affect

A

Glomerulus but also causes tubulointerstial disease you see edema, and inflammatory infiltrate caused by t lymphocytes and monocytes and plasma cels