lupus and diabetes Flashcards
how many classifications of lupus
6
onset of lupus
15-45
how many criteria and how many to fill
4/11 to fill
do patients have nephritic or nephrotic proteinuria
can be both, initially nephritic then progresses to nephrotic usually or can skip straight to nephrotic
name the different stages
- minimal mesangial
- mesangial proliferative
- focal
- diffuse
- membranous
- advanced sclerosis
which is the worst class of lupus
diffuse lupus
what deposition is lupus mainly associated with
subendothelial deposition
which deposit will give you significant proteinuria
subepithelial because now its close to the BM
treament of lupus nephritis hypertension
ACE + ARBS
what drug is solu-medol
methylprednisolone
what antibodies/subsances can be seen on staining and which is the most common
IG G most common but iG M + IG A can ve seen and c3 and c1q
some of the factors involved in diabetic neprhopathy
IGF VEFG TGF- b1 thrombospondin AGE - advanced glycation end products
hall mark findings in diabetes
mesangial expansion
nodules- kimmelstein
glomerulosclerosis
which has a wire looping appearance
diffuse proliferative GN= lupus nephritis, sunednoehtlial deposits and you see a GRANULAR PATTERN
LM:neurtiphil and hyaline thrombi
what will you see on lM in class 4 lupus
hyaline thrombi and neutrophils