lupus and diabetes

Question 1

how many classifications of lupus

Answer 1

6

Question 2

onset of lupus

Answer 2

15-45

Question 3

how many criteria and how many to fill

Answer 3

4/11 to fill

Question 4

do patients have nephritic or nephrotic proteinuria

Answer 4

can be both, initially nephritic then progresses to nephrotic usually or can skip straight to nephrotic

Question 5

name the different stages

Answer 5

1. minimal mesangial
2. mesangial proliferative
3. focal
4. diffuse
5. membranous
6. advanced sclerosis

Question 6

which is the worst class of lupus

Answer 6

diffuse lupus

Question 7

what deposition is lupus mainly associated with

Answer 7

subendothelial deposition

Question 8

which deposit will give you significant proteinuria

Answer 8

subepithelial because now its close to the BM

Question 9

treament of lupus nephritis hypertension

Answer 9

ACE + ARBS

Question 10

what drug is solu-medol

Answer 10

methylprednisolone

Question 11

what antibodies/subsances can be seen on staining and which is the most common

Answer 11

IG G most common but iG M + IG A can ve seen and c3 and c1q

Question 12

some of the factors involved in diabetic neprhopathy

Answer 12

IGF 
VEFG
TGF- b1 
thrombospondin 
AGE - advanced glycation end products

Question 13

hall mark findings in diabetes

Answer 13

mesangial expansion
nodules- kimmelstein
glomerulosclerosis

Question 14

which has a wire looping appearance

Answer 14

diffuse proliferative GN= lupus nephritis, sunednoehtlial deposits and you see a GRANULAR PATTERN

LM:neurtiphil and hyaline thrombi

Question 15

what will you see on lM in class 4 lupus

Answer 15

hyaline thrombi and neutrophils

Question 16

antibodies

Answer 16

double stranded DNA

anti- sm - very specific but not found in all patients

Question 17

which parts of the kidney does lupus affect

Answer 17

Glomerulus but also causes tubulointerstial disease you see edema, and inflammatory infiltrate caused by t lymphocytes and monocytes and plasma cels