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nephro > glomerulonephritis > Flashcards

glomerulonephritis Flashcards

1
Q

different causes of GN

A
  1. infection - post strep
  2. autoimmune - ra, lupus abitglomeular bm disease
  3. deposition - amyloid
  4. metabolic - diabetes
  5. malignancy
  6. drugs- nsaids, anabolic steroids
  7. Hereditary disorders e.g. Alport’s syndrome
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2
Q

what does selective mean

A

only albumins

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3
Q

what is proliferative GN MORE associated with but not a rule

A

nephritic

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4
Q

difference between iGA AND PSGN

A

both after an URTI but IG A will have 1 or 3 day history whereas PSGI is > 1 week ( I think) may have even recoverdd

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5
Q

what is the ubiquitous feature of FGS

A

proteinuria which may be nephrotic or non nephrotic

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6
Q

FGCS - what happens to podocyes

A

atrophy

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7
Q

MCD- hat happens to podocyes

A

effacement

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8
Q

secondary causes of membranous GN

A

malaria, hep b , lupus

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9
Q

membranous gn has a high risk of

A

clots especially in renal vein

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10
Q

typically what’s the progression form pharyngitis to kidney problems in PSGN

A

around 10 days

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11
Q

‘synpharyngitic syndrome’

A

in psgn Short latency period <1 week is suggestive of ‘synpharyngitic syndrome’
corresponding typically to exacerbation of underlying IgA nephropathy

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12
Q

what type pf hematuria is present in PSGN

A

Microscopic in more than two-thirds of cases but can be macroscopic sometimes

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13
Q

classification of hypertension in PSGN

A

mild to moderate and typically goes away after diuresis

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14
Q

main staining pf PSGN

A

C3( always ) AND IG G (varying in intensity ) but in talas table they come together

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15
Q

ubiquitous MCD

A

MASSIVE PROTEINURIA

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16
Q

PATHOGENEISS OF MCD

A

T cells in the blood release cytokines which damage the foot
process of the podocytes (effacement) This leads to selective
proteinuria

17
Q

Type of staining in membranous

A

Granular subepithelial immmune complexes of c3 and IG G

18
Q

Kidney function in membranous

A

Normal and slightly decreased

19
Q

The difference between primary and secondary memrbnois

A

1- antibodies attacking the podocytes (antiphospholase A2 receptor)

No mesanagium

iG G subclass 4

Secondary

Competes deposited

Mesangium

Subclasss 1,2,3

20
Q

What type of proteinuria is membranous

A

Non selective

21
Q

Membranoprolofeative usually affects

A

Children

22
Q

Type 1 and type 2 membrano proliferative

A
  1. Subendothelial + mesangial proliferation

Type 2 : intramembranous- DDD + mesangium

Type 3: subepi, subendo, mesangium

23
Q

Which types of membranoprolifertive have hypocomplimentemia

A

Both

24
Q

Which GN have low complement

A

PSGN and membranoproliferative

25
Q

Where is c3 nephrotic factor found

A

In type 2 membranoproliferative but also can be found in type 1

26
Q

Where is terminal complement nephrotic factor found

A

Mainly in type 3! But can be found in type 1 too and rarely in type 2

27
Q

DDD

A

membranoproliferazive type 2(intramembranous)

28
Q

subepthelial hum like despots of IG G and c3 is

A

PSGN

29
Q

ig m neproptahthy

A

you’ll have regular staining which is dominant in the mesangial area

ELECTRON DENSE DEPOSITS (dx with MCD)

30
Q

which one has irregular staining for iG m

A

FSGS

31
Q

Whas the pathophys for crescent formation

A

Hypergonadotropic hypogonadism indicates a primary gonadal defect (congenital or acquired), while hypogonadotropic hypogonadism suggests a hypothalamic/pituitary process (congenital or acquired)

32
Q

classification of crescneetirc

A

Classification of crescentic GN based on IF and serologic criteria
Type 1 –linear deposits of IgG - anti glomerular basement membrane disease
Type 2 –granular deposits of immunoglobulin – immune complex mediated
Type 3 – few/no immune deposits (pauci – immune) – anti neutrophil cytoplasmic
antibody associated (ANCA associated) – related to small vessel vasculitis! such as weighers granulomatosis
Type 4 – combinations of type 1 and 3
Type 5 – ANCA– negative pauci immune renal vasculitis – 5-10%

33
Q

antiglomerular bM what type of staining

A

LINEAR

34
Q

where do we find the antiphosopholipase receptor

A

primary membranous GN

nephro (11 decks)

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