amyloidosis

Question 1

tx of 2nd type of amyloidosis

Answer 1

1st line- coaching - prevents proteinuria

2nd line- IL-1R antagonist (binds to the receptor preventing from sending a signal)

Question 2

main symptoms of secondary

Answer 2

GI
nephrotic syndroms
hepatosplenomegaly
rare to have heart and nerve involvements

Question 3

which type is more severe

Answer 3

AL - as can involve the heart

Question 4

familial mediterrean fever and tx

Answer 4

AR, in families, accompanied by episode os peritonitis, arthritis and pleuritic usually accompanied by fever and can lead to 2 amulyoidosis

coaching

Question 5

diagnosi s

Answer 5

us- enlargement of organs
staining; congo , H+ E, plane polarised light
biposies: s.c fat, salivary glands
BM biopsy - mm

Question 6

what’s the big NB for amyloidosis

Answer 6

NO HEMATURTIA

Question 7

Other systemic signs

Answer 7

macroglossia
periorbital purpura 
hypotension - neuropathy 
restrictive cardiopathy 
parenthesis

Question 8

RF

Answer 8

familial mediaterrean fever
AGE>60 - natural process
dialysis - cannot remove
race- africans higher risk