Translocation

Question 1

Burkitt leukemia

Answer 1

t(2; 8)(p12;q24)

Question 2

Ph ALL IGH/CRLF2

Answer 2

t(Y;14)(p11;q32)
Ph-like acute lymphoblastic leukemia (ALL) is more common in Hispanic adolescents and is associated with high expression of CRLF2.

Question 3

Ewing sarcoma

Answer 3

EWS-::FLI1

Question 4

t(11;14)(p13;q11.2)

Answer 4

The t(11;14)(p13;q11.2) fuses the T-cell receptor alpha/delta (TCRA/D) locus with LMO2, which occurs in about 7% of pediatric T-ALL cases and does not appear to have prognostic significance.

Question 5

t(9;22)(q34;q11)

Answer 5

t(9;22)(q34;q11) Philadelphia chromosome occurs in about 4% of pediatric B-cell precursor ALL. The Philadelphia chromosome is also seen rarely in T-ALL, but with a frequency less than 1%.

Question 6

t(1;19)(q23;p13)

Answer 6

creates TCF3::PBX1 (E2A::PBX1) fusion and is seen in about 5% of B-cell precursor ALL cases.

Question 7

The t(9;11)(q34;q23)

Answer 7

KMT2A::AF9 fusion and is seen commonly in acute myeloid leukemia and less commonly in B-lineage ALL (especially infants).

Question 8

t(8;22)(q24;q11)

Answer 8

fuses c-MYC to the immunoglobulin lambda gene on chromosome 22

rare recurrent translocation in Burkitt leukemia and lymphoma