Leukocyte

Question 1

Neutrophil azuroohilic granules

Answer 1

Mnemonic: “PLD - Powerful Little Defenders”

Proteinases → Protein degradation
Lysozyme → Antimicrobial
Defensin, myeloperoxidase → Reactive oxygen species
Specific/Secondary Granules

Question 2

Neutrophil azuroohilic granules

Answer 2

Mnemonic: “PLD - Powerful Little Defenders”

Proteinases → Protein degradation
Lysozyme → Antimicrobial
Defensin, myeloperoxidase → Reactive oxygen species
Specific/Secondary Granules

Question 3

Specific / secondary granules

Answer 3

Mnemonic: “LTL - Little Tough Leukocytes Can React”

Lactoferrin → Iron/copper chelator/sequestrator
Transcobalamin → B12 binding
Lysozyme → Antimicrobial
Membrane proteins → Extravasation
Cytochrome B558 → Reactive oxygen species

Question 4

Tertiary Granules

Answer 4

Good Clean Fight” (GCF)

Gelatinase → Digestion
CD11b/CD18 → Ingestion
FcγRIII → Antibody Fc binding

Question 5

Tertiary Granules

Answer 5

Mnemonic: “CDG - Can Digest Germs”

CD11b/CD18 → Ingestion
Gelatinase → Digestion
FcγRIII → Antibody Fc binding

Question 6

Secretory granules neutrophil

Answer 6

Albumin

Question 7

Optimal Cytogenetic Response Definition in CML

Answer 7

> 1%–10% bcr-abl1 in peripheral blood at 6 months after initiation of TK therapy and bcr-abl1 ≤0.1% at 12 months.

Question 8

Major Molecular Response (MMR) Definition in CML

Answer 8

BCR-ABL1 ≤0.1% (International Standardized Ratio)

Marker of long-term progression-free survival