Transfusion Reactions Flashcards
When a transfusion fatality or transfusion related serous morbidity occurs, when and to whom should it be reported?
FDA
- Telephone <24 hours
- Writein <7 days
What is the most common type of transfusion reactions?
Febrile, nonhemolytic (1 in 200 trxs)
FNHTR:
- Definition
- Mediated by
- 1-2C increase in temp.
- Cytokines released by WBCs in the stored unit of blood
What is the second MC transfusion reaction?
Allergic (1 in 300 trxs)
Allergic transfusion reactions are mediated by what?
-Who is more susceptible to these reactions?
Allergic (IgE mediated) reaction to plasma proteins
-IgA deficient recipients (react to IgA in donor plasma)
What units should an IgA deficient recipient receive after suffering anaphylaxis?
-Alternate
IgA deficient units
-Washed units
Clinical presentation of acute Intravascular hemolysis. (6)
- Fever
- Chills
- Back pain
- Pain at Infusion site
- Hypotension
- DIC
Clinical presentation of acute Extravascular hemolysis. (3)
Often asymptomatic
- Pallor
- Hyperbilirubinemia
- Anemia
Laboratory findings - Intra Vs. Extravascular Hemolysis:
-Positive DAT
Both
Laboratory findings - Intra Vs. Extravascular Hemolysis:
-Pink serum
Intravascular
Laboratory findings - Intra Vs. Extravascular Hemolysis:
-Hyperbilirubinemia
Extravascular
Laboratory findings - Intra Vs. Extravascular Hemolysis:
-Hemoglobinuria
Intravascular
Laboratory findings - Intra Vs. Extravascular Hemolysis:
-Coagulation abnormalities
Intravascular
Laboratory findings - Intra Vs. Extravascular Hemolysis:
-Schistocytes on smear
Intravascular
Laboratory findings - Intra Vs. Extravascular Hemolysis:
-Spherocytes on smear
Extravascular
