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Boards.CP.Blood Bank > Grans, Plasma, Cryo, Concentrates > Flashcards

Grans, Plasma, Cryo, Concentrates Flashcards

1
Q

Granulocyte Concentrates:

-Storage

A

20-24 C up to 24 hours

-withOUT agitation

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2
Q

Granulocyte Concentrates:

-Each unit contains (3)

A
  • WBC (10^10)
  • Platelets (large number)
  • RBCs (contaminating)
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3
Q

Granulocyte Concentrates:

-Indications (2)

A
  • Neutropenic Sepsis

- Fungal infections unresponsive to standard therapy

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4
Q

Granulocyte Concentrates:

  • Dosing
  • ABO crossmatch
  • Irradiated
  • Leukoreduced
A
  • No agreed upon dose
  • Must be ABO crossmatch compatible w/ recipient
  • Must be irradiated
  • NEVER leukoreduced
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5
Q

Plasma:

  • FFP storage
  • Expiration (2)
A

-(-)18 degrees C
Expires:
-1 year at -18 C
-7 years at

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6
Q

FP24 is depleted of what factors (vs FFP)?

-Useful for all indications for FFP, except what?

A 
Factors V(5)/VIII(8)
-DIC
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7
Q

Granulocyte Concentrates:

-Each unit contains (3)

A
  • WBC (10^10)
  • Platelets (large number)
  • RBCs (contaminating)
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8
Q

Plasma:

-FP24 preparation

A

Plasma frozen between >8 hours and <24 hours.

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9
Q

Plasma/FFP compatibility:

  • 1st choice
  • 2nd choice
A

Contains ABO antibodies; should be compatible with recipient red cells.

  • ABO identical - 1st choice
  • Type AB (universal plasma donor)* - 2nd choice

*Contains NO antibodies

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10
Q

FFP:

  • must be thawed at what temp?
  • after thawing expires?
A

Thawed at 30-37 C

-Expires in 24 hours

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11
Q

FFP:

  • Total Volume
  • Amt. of Coag Factors
  • Fibrinogen
A

200 mL

  • 1 IU/mL of ALL coagulation factors*
  • 2 mg of fibrinogen/mL

*1 IU of coagulation factor is that amount contained in 1 mL of normal plasma

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12
Q

Plasma/FFP Indications. (4)

A
  • Multiple factor deficiencies
  • C1 Esterase Inhibitor deficiency
  • Warfarin Skin Necrosis (Rapid infusion)
  • Warfarin reversal (last resort)
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13
Q

What is the appropriate treatment for single factor deficiencies? (step-wise; 3)

A
  1. Recombinant/Factor concentrates
  2. Cryoprecipitate
  3. Plasma
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14
Q

FFP Dosing:

  • Adults
  • Neonates
A
  • 2 units for Adults

- 10-15 mL/kg for neonates (and adults)

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15
Q

Cryoprecipitate Indications/Uses. (5)

A
  • DIC/Fibrinogen deficiency (<100 mg/dL)
  • Uremic pts w/ bleeding
  • Factor XIII (13) deficiency
  • vWD (1st - DDAVP)
  • Fibrin “glue”
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16
Q

Plasma/FFP compatibility:

  • 1st choice
  • 2nd choice
A

Contains ABO antibodies; should be compatible with recipient red cells.

  • ABO identical - 1st choice
  • Type AB (universal plasma donor)* - 2nd choice

*Contains NO antibodies

17
Q

Plasma/FFP compatibility:

-Rh type

A

Donor Rh type should not affect product choice

-No need to give RhIg

18
Q

How do you make Cryoprecipitate?

A
  1. Thaw FFP to 1-6 C
  2. Centrifuge
  3. Precipitate forms (cold insoluble portion of plasma)
  4. Remove thawed plasma
  5. -18C within 1 hour
19
Q

Cyroprecipitate - Expiration:

  • Storage
  • After thawing
A
  • 1 year at -18C

- 6 hours, unless pooled, then expires in 4 hours

20
Q

Cryoprecipitate:

  • Total Volume
  • Fibrinogen
  • Factor VIII (8)
  • Also rich in what (2)
  • Does NOT contain (1)
A

Cryprecipitate:

  • 15 mL (total volume)
  • > 150 mg Fibrinogen
  • 80 IU of Factor VIII (8)
  • vWF/FactorXIII (13)
  • NO Factor V (5)
21
Q

T/F: One unit of cryoprecipitate contains the amount of factors present in 1-2 units of FFP, but in a significantly small volume.

A

True

*1 unit of FFP has the volume of 20 units of cryo

22
Q

What is the half-life of Factor VIII (8)?

A

12 hours

23
Q

Cryo should not be used alone in DIC, what should also be given?

A

FFP

*Cryo lacks certain factors, notably F5

24
Q

What is the usual dose of Cryo in adults?

A

10 bags, pooled

25
Q

What is the expected rise in fibrinogen?

  • 1 unit of Cryo
  • 1 dose of Cryo (10 bags)
A
  • 7 mg/dL

- 70 mg/dL

26
Q

Factor VII (7) concentrate indications. (3)

A
  • Factor VII (7) deficiency (Inherited)
  • Anti-FVIII (8) inhibitors
  • Anti-FIX (9) inhibitors
27
Q

Factor VIII (8) concentrate indications. (2)

A
  • Hemophilia A (treatment/prophylaxis)
  • von Willebrand disease*

*Humate-P formulation contains sufficient vWF

28
Q

Factor IX (9) concentrate:

  • Indication
  • Half-life
  • Intravascular Recovery
A
  • Hemophilia B
  • T1/2 - 24 hours
  • Intravascular recovery - 50%*

*Factor VIII (8) Intravascular recovery is 100%

29
Q

Estimating the dose of FVIII (8):

  • 30% activity
  • 50% activity
  • 100% activity
A

Estimating the dose of FVIII (8):

  • 30% activity: 15 IU/kg
  • 50% activity: 25 IU/kg
  • 100% activity: 50 IU/kg

Boards.CP.Blood Bank (13 decks)

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