Antigen/Antibody FACTS Flashcards
RBC antigen associations:
-Fy(a-b-)
Duffy- confers resistance to P. vivax
- Duffy antigen is receptor for P. vivax
- More common in blacks
RBC antigen associations:
-McLeod Phenotype
Lack of Kx antigen (mutation in KX gene)
- Chronic Granulomatous disease
- Acanthocytosis
- Late onset muscular dystrophy-like syndrome (neuroacanthocytosis; Elevated CK)
RBC antigen associations:
-Anti-P
- Paroxysmal Cold Hemoglobinuria (PCH)
- Viral infections in kids (syphilis historically)
RBC antigen associations:
-Anti-I
- Mycoplasma pneumoniae infections
- Lymphomas
RBC antigen associations:
-Anti-i
EBV infection (mononucleosis)
RBC antigen associations:
-Anti-Nf
Renal Dialysis
-Exposure to formaldehyde
RBC antigen associations:
-Acquired B phenotype
- Colorectal carcinoma
- Intestinal obstruction
- Gram NEG sepsis
RBC antigen associations:
-Rh Null
Hereditary stomatocytosis (HS)
RBC antigen associations:
-Diego negative
Diego is an epitope on band 3 protein
- Band 3 deficiency causes:
- -HS
- -Acanthocytosis
- -Hereditary Elliptocytosis
RBC antigen associations:
-Gerbich negative (Leach phenotype)
Gerbich is an epitope on Glycophorin C
-Cause of Hereditary Elliptocytosis
Naturally occuring antibodies (8)
- I/i
- ABO
- Le
- Lu
- M
- N
- P
Antigens that display dosage. (5)
- MNS
- Kidd
- C/e
- E/e
- Duffy
Antibodies that react at Room Temp. (5)
Anti-
- M
- N
- P1
- Le(a)
- Le(b)
Antibodies that are nearly always clinically Insignificant. (6)
ANTI-
- M
- N
- P1
- Lewis
- Lutheran
- I
The 4 most common antibodies in Immediate HTR.
- Anti-A
- Anti-Kell
- Anti-Jk(a)
- Anti-Fy(a)
