Transfusion medicine, Thrombophilia Flashcards

1
Q

Each unit of platelets results in a increase in platelets of how much

A

20K-25K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Causes of platelet transfusion refractoriness (inappropriate rise in platelets)

A

Sepsis, DIC, drugs, splenic sequestration, alloimmunization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

FFP is used to replace

A

coag factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cryoprecipitate consists of ____ and is used to manage ___

A

Factor VIII, Fibrinogen, vWF

DIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Inactivated 4fPCC (ksentra) contains

A

Factor II, VII, IX, X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Inactivated 4fPCC is indicated for

A

warfarin associated bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Threshold to transfuse platelets when there is no risk for bleeding

A

10K-20K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Threshold to transfuse platelets when there is intracranial bleeding

A

100K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Threshold to transfuse platelets when there is bleeding or planned surgery

A

50K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Delayed hemolytic transfusion reaction occurs ____ days after transfusion and is caused by

A

2-10

emergence of new alloantibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

TRALI occurs

A

during or within 6 hours of transfusing platelets, pRBC or FFP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Allergic transfusion reaction is mediated by

A

IgE on mast cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

People most at risk for allergic transfusion reaction

A

People with IgA deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Reduced the number of leukocytes present in the transfused product

A

Leukoreduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Leukoreduction reduces

A

platelet transfusion refractoriness, febrile nonhemolytic transfusion reactions and transmission of CMV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Prevents transfusion-associated GVHD

A

Irradiation

17
Q

Removes proteins in the plasma in erythrocyte and platelet transfusions

A

Washing

18
Q

Washing is used in patients with

A

history of allergic reactions, IgA def, Complement-dependent AIHA

19
Q

Increased risk for VTE

A

Thrombophilia

20
Q

50-60% of inherited thrombophilia is caused by

A

Prothrombin gene mutations, protein C deficiency, Factor V Leiden mutation

21
Q

Factor V Leiden testing

A

Assay to determine resistance to activated Protein C + genetic analysis

22
Q

Prothrombin gene mutation testing

A

genetic test

23
Q

Examples of anti-phospholipid antibodies

A

Lupus anticoagulants- prolong PTT

Anticardiolipin antibodies- measure with IgM and IgG

24
Q

Associated with highest risk for thrombosis and pregnancy loss

A

Lupus anticoagulant
Anti-cardiolipin antibody
Anti-B2-GPI