Transfusion medicine, Thrombophilia

Question 1

Each unit of platelets results in a increase in platelets of how much

Answer 1

20K-25K

Question 2

Causes of platelet transfusion refractoriness (inappropriate rise in platelets)

Answer 2

Sepsis, DIC, drugs, splenic sequestration, alloimmunization

Question 3

FFP is used to replace

Answer 3

coag factors

Question 4

Cryoprecipitate consists of ____ and is used to manage ___

Answer 4

Factor VIII, Fibrinogen, vWF

DIC

Question 5

Inactivated 4fPCC (ksentra) contains

Answer 5

Factor II, VII, IX, X

Question 6

Inactivated 4fPCC is indicated for

Answer 6

warfarin associated bleeding

Question 7

Threshold to transfuse platelets when there is no risk for bleeding

Answer 7

10K-20K

Question 8

Threshold to transfuse platelets when there is intracranial bleeding

Answer 8

100K

Question 9

Threshold to transfuse platelets when there is bleeding or planned surgery

Answer 9

50K

Question 10

Delayed hemolytic transfusion reaction occurs ____ days after transfusion and is caused by

Answer 10

2-10

emergence of new alloantibody

Question 11

TRALI occurs

Answer 11

during or within 6 hours of transfusing platelets, pRBC or FFP

Question 12

Allergic transfusion reaction is mediated by

Answer 12

IgE on mast cells

Question 13

People most at risk for allergic transfusion reaction

Answer 13

People with IgA deficiency

Question 14

Reduced the number of leukocytes present in the transfused product

Answer 14

Leukoreduction

Question 15

Leukoreduction reduces

Answer 15

platelet transfusion refractoriness, febrile nonhemolytic transfusion reactions and transmission of CMV

Question 16

Prevents transfusion-associated GVHD

Answer 16

Irradiation

Question 17

Removes proteins in the plasma in erythrocyte and platelet transfusions

Answer 17

Washing

Question 18

Washing is used in patients with

Answer 18

history of allergic reactions, IgA def, Complement-dependent AIHA

Question 19

Increased risk for VTE

Answer 19

Thrombophilia

Question 20

50-60% of inherited thrombophilia is caused by

Answer 20

Prothrombin gene mutations, protein C deficiency, Factor V Leiden mutation

Question 21

Factor V Leiden testing

Answer 21

Assay to determine resistance to activated Protein C + genetic analysis

Question 22

Prothrombin gene mutation testing

Answer 22

genetic test

Question 23

Examples of anti-phospholipid antibodies

Answer 23

Lupus anticoagulants- prolong PTT

Anticardiolipin antibodies- measure with IgM and IgG

Question 24

Associated with highest risk for thrombosis and pregnancy loss

Answer 24

Lupus anticoagulant
Anti-cardiolipin antibody
Anti-B2-GPI