Transfusion medicine, Thrombophilia Flashcards
Each unit of platelets results in a increase in platelets of how much
20K-25K
Causes of platelet transfusion refractoriness (inappropriate rise in platelets)
Sepsis, DIC, drugs, splenic sequestration, alloimmunization
FFP is used to replace
coag factors
Cryoprecipitate consists of ____ and is used to manage ___
Factor VIII, Fibrinogen, vWF
DIC
Inactivated 4fPCC (ksentra) contains
Factor II, VII, IX, X
Inactivated 4fPCC is indicated for
warfarin associated bleeding
Threshold to transfuse platelets when there is no risk for bleeding
10K-20K
Threshold to transfuse platelets when there is intracranial bleeding
100K
Threshold to transfuse platelets when there is bleeding or planned surgery
50K
Delayed hemolytic transfusion reaction occurs ____ days after transfusion and is caused by
2-10
emergence of new alloantibody
TRALI occurs
during or within 6 hours of transfusing platelets, pRBC or FFP
Allergic transfusion reaction is mediated by
IgE on mast cells
People most at risk for allergic transfusion reaction
People with IgA deficiency
Reduced the number of leukocytes present in the transfused product
Leukoreduction
Leukoreduction reduces
platelet transfusion refractoriness, febrile nonhemolytic transfusion reactions and transmission of CMV