Anemia

Question 1

Normocytic anemia with increased absolute reticulocyte count (>100,000/uL) relfects

Answer 1

Bleeding or hemolysis
or
Response to therapy (iron, folate, B12)

Question 2

Normocytic anemia with low retic count

Answer 2

inflammation with deficient erythropoietin,
nutritional deficiency,
hypometabolism,
primary hematopoietic disorder

Question 3

A serum ferritin >___ rules out iron deficiency

Answer 3

100

Question 4

If basophilic stippling is found on smear

Answer 4

check lead level

Question 5

If target or sickle cells are on smear

Answer 5

check hemoglobin electrophoresis

Question 6

If spherocytes are found

Answer 6

Check DAT

Question 7

Signs of IDA

Answer 7

RLS, Hair loss, spoon nails

Question 8

For Microcytic anemia, after checking Iron, ferritin and TIBC, you should check

Answer 8

Hemoglobin electrophoresis if studies are normal

Colonoscopy in positive FIT/FOBT or IDA is present

Question 9

Patients with serum ferritin < 14

Answer 9

are iron deficient

Question 10

Least expensive iron replacement

Answer 10

iron sulfate, every other day, for 6 months

Question 11

If young woman with IDA does not respond to oral iron therapy and has IBS, check

Answer 11

test for celiac disease.

Question 12

Drugs affecting folate metabolism/ DNS synthesis

Answer 12

alcohol, zidovudine, hydroxyurea, methotrexate

Question 13

MCV >115 is always

Answer 13

megaloblastic disorders

Question 14

In megaloblastic anemia, you also get penia of other cell lines

Answer 14

leukopenia, thrombocytopenia

Question 15

Macrocytic anemia with large target cells and echinocytes (burr cells with spiny erythrocyte membrane projections) signifies

Answer 15

liver disease

Question 16

Macrocytic anemia with large target cells, acanthocytes ( few spiny projection on erythrocyte membrane), howell- jolly bodies and nucleated erythrocytes signifies

Answer 16

Diminished spleen function

Question 17

If serum B12 levels are borderline low.. order

Answer 17

MMA and homocysteine

Question 18

Elevated homocysteine and MMA signifies

Answer 18

B12 deficiency

Question 19

Elevated homocysteine and normal MMA is associated with

Answer 19

folate deficiency

Question 20

Random cause for elevated MCV

Answer 20

Reticulocytes

Question 21

B12 deficiency can present with

Answer 21

subacute combined degeneration of spinal column (neuro symptoms)without anemia

Question 22

MCV in hemolytic anemia is

Answer 22

elevated (elevated reticulocytes

Question 23

Congenital Hemolytic Anemias

Answer 23

Sickle cell
Hereditary spherocytosis
G6PD deficiency
Thalassemia