Thrombocytopenia

Question 1

Causes of non-immune thrombocytopenia

Answer 1

Toxins (alcohol)
Idiosyncratic drug reactions
metastatic cancer
infection
B12, folate
Acute leukemia, MDS, Aplastic anemia

Question 2

Consumptive thrombocytopenia

Answer 2

Thrombocytopenia with schistocytes

Question 3

Consumptive thrombocytopenia suggests

Answer 3

DIC, TTP and HUS

Question 4

Isolated thrombocytopenia in a patient without other causes

Answer 4

Immune thrombocytopenia

Question 5

Immune thrombocytopenia occurs when

Answer 5

antibodies targeting platelet antigens mediate destruction

Question 6

Antibodies in ITP arise in these three distinct clinical settings

Answer 6

Drug induced
Disease associated
Idiopathic

Question 7

Drug induced ITP is linked to

Answer 7

heparin, antibiotics

New drugs or herbal remedy

Question 8

Disease associated immune thrombocytopenia causes

Answer 8

HIV, Hep C, Hyperthyroidism, Hypothyroid, SLE, lymphoproliferative malignancy

Question 9

Idiopathic ITP (immune thrombocytopenic purpura)

Answer 9

blood smear with reduced platelets. Normal erythrocytes and myeloid

Question 10

Anemia does not exclude

Answer 10

ITP if anemia can be explained by bleeding

Question 11

Platelet associated antibody is

Answer 11

not helpful

Question 12

Schistocytes

Answer 12

DIC, TTP-HUS, HELLP

Question 13

Platelet clumps

Answer 13

psuedothrombocytopenia caused by EDTA-dependent agglutinins.

Repeat count using citrated or heparinized tube

Question 14

Teardrop (erythrocyte) cells, disorders in two cell lines

Answer 14

MDS

Question 15

Anemia, leukopenia, lymphocytosis

Answer 15

Aplastic anemia

Question 16

Pancytopenia, macrocytosis, macroovalocytes, hypersegmented neutrophils

Answer 16

B12 or Folate def

Question 17

Thrombocytopenia following heparin administration

Answer 17

HIT

Question 18

Thrombocytopenia 5-10 days after blood transfusion

Answer 18

Posttransfusion purpura

Question 19

Cirrhosis and thrombocytopenia

Answer 19

splenic sequestration

Question 20

Initiate therapy for ITP when

Answer 20

platelet count <30K, or with bleeding

Question 21

ITP=

Answer 21

Immune thrombocytopenia

Question 22

First line treatment for ITP

Answer 22

Glucocorticoids

Question 23

Treatment for Glucocorticoid resistant ITP or severe bleeding

Answer 23

IVIG

Question 24

ITP unresponsive to drug therapy or relapse after glucocorticoids are tapered

Answer 24

Splenectomy, rituximab

Question 25

Refractory ITP

Answer 25

Can try thrombopoiesis stimulating agents