General

Question 1

Some patients with Aplastic Anemia have an associated…

Answer 1

Thymoma

Question 2

4 Characteristics of Paroxysmal Nocturnal Hemoglobinuria

Answer 2

1. Chronic Hemolytic Anemia
2. Iron deficiency through urinary losses
3. Venous thromboembolism (including Budd Chiari)
4. Pancytopenia

Question 3

Paroxysmal Nocturnal Hemoglobinuria cell surface markers

Answer 3

CD55, CD59

Question 4

3 disorders comprised of acquired hematopoietic stem cell defects

Answer 4

1. Aplastic Anemia
2. PNH
3. MDS

Question 5

Treatment for Aplastic Anemia

Answer 5

Withdraw offending agent
Cyclosporine and Antithymocyte
Allogeneic HSCT: Curative for patients <50 yo

Question 6

Treatment for PNH

Answer 6

Eculizumab for symptom reduction
HSCT- long term survival
Prophylactic anticoagulation, iron and folate supplement

Question 7

Causes of Pure red cell aplasia

Answer 7

Pregnancy, Thymoma, malignancy

Viral or drug toxity

Question 8

Bone marrow findings in pure red cell aplasia

Answer 8

Clonal CD57 positive T cells

Question 9

Must have imaging for PRCA

Answer 9

CT to rule out thymoma

Question 10

Treatment PRCA

Answer 10

Same as aplastic anemia cyclosporine, antithymocyte
Prednisone
Thymectomy
IVIG for AIDS and Parvo B19 patients

Question 11

Treatment for PRCA with large granular lymphocytosis

Answer 11

methotrexate or cyclosproine

Question 12

Causes of Neutropenia

Answer 12

Carbamazepine, Phenytoin
PTU
Cephalosporins, Bactrim

Question 13

Felty syndrome

Answer 13

RA, splenomegaly, neutropenia

Question 14

Immune associated neutropenia

Answer 14

Felty syndrome

Question 15

Treatment for Felty

Answer 15

cyclosporine
antithymocite
prednisone

Question 16

What can be treated with cyclosporine and antithymocyte

Answer 16

Aplastic Anemia
Felty
PRCA

Question 17

Age for MDS

Answer 17

> 60

Question 18

Differentials for MDS

Answer 18

B12/Folate deficiency
Alcohol, drug
Acute leukemia
Myeloproliferative syndromes

Question 19

MDS is precursor to

Answer 19

Acute leukemic syndromes

Question 20

MDS Bone marrow findings

Answer 20

hypercellular marrow, dysplastic erythroid precursors

Question 21

MDS will have cytopenia in at least

Answer 21

two lines

Question 22

Morphologic abnormalities of erythrocytes in MDS

Answer 22

macrocytosis with nucleated erythrocytes and teardrop cells

Question 23

Subtype of MDS with specific therapy

Answer 23

-5q syndrome

Question 24

Risk scale for MDS

Answer 24

IPSS-R

Question 25

High IPSS-R score requires

Answer 25

treatment to prevent AML

Question 26

Treatment for MDS

Answer 26

HSCT for young people

Azacytidine and decitabine to people at high risk for AML and not candidate for HSCT

Question 27

Treatment for people at high risk for AML and not a candidate for HSCT

Answer 27

Azacytidine and Decitabine

Question 28

Treatment of -5q syndrome

Answer 28

Lenalidomide