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Hematology > Other cell lines > Flashcards

Other cell lines Flashcards

1
Q

In hypereosinophilic syndrome, eosinophils are greater than

A

1500

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2
Q

In HES, eosinophils infiltrate

A

spleen, heart, liver, lymphnodes

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3
Q

In primary HES there is molecular activation of

A

Platelet derived growth factor receptor (PDGFR) alpha or beta

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4
Q

Treatment for HES

A

Imatinib, glucocorticoid

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5
Q

Causes of eosinophilia

A
  1. Eosinophilic granulomatosis with polyangiitis
  2. Helminthic
  3. Idiopathic
  4. Neoplasia
  5. Allergy
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6
Q

ALL is comprised of

A

precursor T or B cells

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7
Q

ALL characteristics

A

bulky LAD

Younger

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8
Q

ALL Treatment

A

Combo chemo then HSCT

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9
Q

AML patients never have…

A

LAD, hepatosplenomegaly

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10
Q

AML seems like

A

the worst one to get- complicated by bleeding, thrombocytopenia, infection

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11
Q

How to diagnose AML

A

elevated leukocyte, anemia, thrombocytopenia, blasts on smear

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12
Q

Hallmarks of AML

A

Auer rods, gingival hyperplasia, leukemia cutis

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13
Q

Confirm diagnosis of AML with

A

BMBx- >20% blasts

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14
Q

APL

A

t 15;17

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15
Q

APL complications

A

bleeding due to fibrinolysis and DIC

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16
Q

APL

A

t 15;17, retinoic avvcid receptor

17
Q

Very high leukocytosis, CNS symptoms, hypoxia, diffuse infiltrates on CXR

A

Leukostasis syndrome

18
Q

AML: favorable risk

A

t(8:21), inv (16), t(15:17)

19
Q

High risk genetic abnormality AML

A

-5 -7, -5q, 3q

20
Q

Older patients with acute leukemia can present with

A

pancytopenia

21
Q

APL treatment

A

ATRA- all trans retinoic acid

22
Q

People taking ATRA or arsenic trioxide are at risk for developing

A

Differentiation syndrom

23
Q

Fever, pulmonary infiltrates, hypoxemia, hyperleukocytosis in patients taking ATRA

A

Differentiation syndrome

24
Q

Treatment for differentiation syndrome

A

Dexamethasone

25
Q

Treatment for leukostasis syndrome

A

leukapheresis

26
Q

For high risk AML patients in first complete remission, first relapse or second complete remission

A

Allogeneic and autologous HSCT

Hematology (11 decks)

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