Other cell lines Flashcards
In hypereosinophilic syndrome, eosinophils are greater than
1500
In HES, eosinophils infiltrate
spleen, heart, liver, lymphnodes
In primary HES there is molecular activation of
Platelet derived growth factor receptor (PDGFR) alpha or beta
Treatment for HES
Imatinib, glucocorticoid
Causes of eosinophilia
- Eosinophilic granulomatosis with polyangiitis
- Helminthic
- Idiopathic
- Neoplasia
- Allergy
ALL is comprised of
precursor T or B cells
ALL characteristics
bulky LAD
Younger
ALL Treatment
Combo chemo then HSCT
AML patients never have…
LAD, hepatosplenomegaly
AML seems like
the worst one to get- complicated by bleeding, thrombocytopenia, infection
How to diagnose AML
elevated leukocyte, anemia, thrombocytopenia, blasts on smear
Hallmarks of AML
Auer rods, gingival hyperplasia, leukemia cutis
Confirm diagnosis of AML with
BMBx- >20% blasts
APL
t 15;17
APL complications
bleeding due to fibrinolysis and DIC
APL
t 15;17, retinoic avvcid receptor
Very high leukocytosis, CNS symptoms, hypoxia, diffuse infiltrates on CXR
Leukostasis syndrome
AML: favorable risk
t(8:21), inv (16), t(15:17)
High risk genetic abnormality AML
-5 -7, -5q, 3q
Older patients with acute leukemia can present with
pancytopenia
APL treatment
ATRA- all trans retinoic acid
People taking ATRA or arsenic trioxide are at risk for developing
Differentiation syndrom
Fever, pulmonary infiltrates, hypoxemia, hyperleukocytosis in patients taking ATRA
Differentiation syndrome
Treatment for differentiation syndrome
Dexamethasone
Treatment for leukostasis syndrome
leukapheresis
For high risk AML patients in first complete remission, first relapse or second complete remission
Allogeneic and autologous HSCT
