Transfusion Medicine Flashcards
What are the major blood systems in dogs?
8 total, but we care about DEA and Dal
What are the most antigenic blood types in dogs?
DEA 1.1 (~45% of population)
DEA 1.2 (~20% of population)
Do dogs have naturally occurring isoantibodies?
No
What blood type is not always expressed in Dalmatians?
Dal
What dog blood types are “universal donors”?
DEA 4 and 6
What are the major blood systems in the cat?
AB system
Mik system
Do cats have a “universal donor”?
No
Do cats have naturally occurring isoantibodies?
YES!!! Blood type all cats prior to transfusion.
Which feline blood type is associated with strong isoantibodies?
Type B has STRONG isoantibodies against Type A
What is the “universal recipient” of cats?
Type AB
Are most cats Mik positive or Mik negative?
Mik positive
What are the two most antigenic blood types in horses?
Aa and Qa (want Aa and Qa negative donors)
What can sensitize cows to foreign RBC antigens?
Vaccines of blood origin
How many blood systems do horses have?
7
What is the general mechanism of Neonatal Isoerythrolysis?
Foal inherits RBC Ags from sire
First foal sensitizes mare to RBC Ags (transplacental hemorrhage late-gest., transfusion, tissue-based vaccine)
Second foal with RBC Ags from sire
Second foal ingests colostrum with antigens against sire RBCs
2-5 days later, foal may show problems
Who is the best transfusion donor for foals with neonatal isoerythrolysis?
The mare
In a major cross-match, what is tested in the recipient and in the donor?
Tests compatibility of recipient serum with donor RBCs
How do you interpret a cross-match?
Agglutination = Positive (bad)
No agglutination or just rouleaux = Negative (good)
What do you need to watch for with greyhound donors?
Babesia
What species do you always blood type?
Cats
What species do you cross-match?
Dogs
What is the difference between blood-typing and cross-matching?
Blood-typing = Identifying specific antigen Cross-matching = Identifying antibodies against RBC antigens
What is the general mechanism of acute hemolytic transfusion reactions?
Intravascular hemolysis, severe reaction against donor blood.
What is the general mechanism of delayed hemolytic transfusion reactions?
Extravascular hemolysis, usually mild reaction 24h to 2-3 weeks post-transfusion
