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Clinical Pathology > Transfusion Medicine > Flashcards

Transfusion Medicine Flashcards

1
Q

What are the major blood systems in dogs?

A

8 total, but we care about DEA and Dal

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2
Q

What are the most antigenic blood types in dogs?

A

DEA 1.1 (~45% of population)

DEA 1.2 (~20% of population)

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3
Q

Do dogs have naturally occurring isoantibodies?

A

No

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4
Q

What blood type is not always expressed in Dalmatians?

A

Dal

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5
Q

What dog blood types are “universal donors”?

A

DEA 4 and 6

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6
Q

What are the major blood systems in the cat?

A

AB system

Mik system

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7
Q

Do cats have a “universal donor”?

A

No

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8
Q

Do cats have naturally occurring isoantibodies?

A

YES!!! Blood type all cats prior to transfusion.

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9
Q

Which feline blood type is associated with strong isoantibodies?

A

Type B has STRONG isoantibodies against Type A

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10
Q

What is the “universal recipient” of cats?

A

Type AB

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11
Q

Are most cats Mik positive or Mik negative?

A

Mik positive

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12
Q

What are the two most antigenic blood types in horses?

A

Aa and Qa (want Aa and Qa negative donors)

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13
Q

What can sensitize cows to foreign RBC antigens?

A

Vaccines of blood origin

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14
Q

How many blood systems do horses have?

A

7

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15
Q

What is the general mechanism of Neonatal Isoerythrolysis?

A

Foal inherits RBC Ags from sire
First foal sensitizes mare to RBC Ags (transplacental hemorrhage late-gest., transfusion, tissue-based vaccine)
Second foal with RBC Ags from sire
Second foal ingests colostrum with antigens against sire RBCs
2-5 days later, foal may show problems

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16
Q

Who is the best transfusion donor for foals with neonatal isoerythrolysis?

A

The mare

17
Q

In a major cross-match, what is tested in the recipient and in the donor?

A

Tests compatibility of recipient serum with donor RBCs

18
Q

How do you interpret a cross-match?

A

Agglutination = Positive (bad)

No agglutination or just rouleaux = Negative (good)

19
Q

What do you need to watch for with greyhound donors?

A

Babesia

20
Q

What species do you always blood type?

A

Cats

21
Q

What species do you cross-match?

A

Dogs

22
Q

What is the difference between blood-typing and cross-matching?

A 
Blood-typing = Identifying specific antigen
Cross-matching = Identifying antibodies against RBC antigens
23
Q

What is the general mechanism of acute hemolytic transfusion reactions?

A

Intravascular hemolysis, severe reaction against donor blood.

24
Q

What is the general mechanism of delayed hemolytic transfusion reactions?

A

Extravascular hemolysis, usually mild reaction 24h to 2-3 weeks post-transfusion

Clinical Pathology (9 decks)

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