Transfusion

Question 1

mild allergic reaction, mediated? treatment?

Answer 1

IGE histamine mediated, stop infusion the antihistamine, can restart if sx resolve

Question 2

Acute hemolytic reaction due to? presentation?

Answer 2

ABO incompatibility, type II HSN IgG/fever flank pain

Question 3

DHTR timing? mediated?

Answer 3

7-14 post transfusion/ ab induced

Question 4

diagnosis of DHTR

Answer 4

positive DAT test

Question 5

febrile non hemolytic reaction mediated?

Answer 5

recipient ab against stored product

Question 6

TRALI timing? presentation?

Answer 6

within 6 hrs/ hypotension, fever, infiltrates, normal JVP

Question 7

TACO difference from TRALI?

Answer 7

no systemic symptoms, signs of volume overload

Question 8

why hypocalcemia in transfusion?

Answer 8

chelation ofn calcium by citrate in blood

Question 9

hemochromatosis triad? tx?

Answer 9

hyperpigmentation, diabetes, arthritis/phlebotomy

Question 10

skin, liver, diarrhea in a hodgins patient post transfusion?

Answer 10

tranfusion related GVHD

Question 11

rash of GVHD?

Answer 11

mac pap morbilliform face palms soles to trunk

Question 12

epidermal lymphocytic infiltrates with vacuolization of basal membrane?

Answer 12

GVHD skin bx

Question 13

RF for transfusion related GVHD?

Answer 13

hodgkins

Question 14

how to prevent transfusion related GVHD?

Answer 14

irradiated blood

Question 15

MC bacteria transmitted through transfusion?

Answer 15

yersinia enterocolitica

Question 16

transfusion can lead to what of RBC?

Answer 16

hemolysis

Question 17

MOA hemolysis post transfusion?

Answer 17

inc ROS, inc cytokines

Question 18

composition of whole blood is deficiency in what?

Answer 18

deficient in clotting factors, contains potassium ammonia and hydrogen ions

Question 19

serum ab against donor HLA antigens?

Answer 19

febrile non hemolytic transfusion reaction

Question 20

manifestation of IgA deficiency in transfusion

Answer 20

anaphylactic reaction

Question 21

lab test positive in acute hemolytic transfusion reaction?

Answer 21

direct coombs

Question 22

how to prevent CMV transmission in IC during blood transfusion?

Answer 22

leukoreduction

Question 23

what to do to a transfusion for patient with allergic reactions or IGA deficiency?

Answer 23

washed

Question 24

how to prevent GVHD in patients during blood transfusion?

Answer 24

Irradiation of blood

Question 25

why can you develop alkalosis from blood transfusion?

Answer 25

citrate load can lead to hypokalemia