Transfusion Flashcards
mild allergic reaction, mediated? treatment?
IGE histamine mediated, stop infusion the antihistamine, can restart if sx resolve
Acute hemolytic reaction due to? presentation?
ABO incompatibility, type II HSN IgG/fever flank pain
DHTR timing? mediated?
7-14 post transfusion/ ab induced
diagnosis of DHTR
positive DAT test
febrile non hemolytic reaction mediated?
recipient ab against stored product
TRALI timing? presentation?
within 6 hrs/ hypotension, fever, infiltrates, normal JVP
TACO difference from TRALI?
no systemic symptoms, signs of volume overload
why hypocalcemia in transfusion?
chelation ofn calcium by citrate in blood
hemochromatosis triad? tx?
hyperpigmentation, diabetes, arthritis/phlebotomy
skin, liver, diarrhea in a hodgins patient post transfusion?
tranfusion related GVHD
rash of GVHD?
mac pap morbilliform face palms soles to trunk
epidermal lymphocytic infiltrates with vacuolization of basal membrane?
GVHD skin bx
RF for transfusion related GVHD?
hodgkins
how to prevent transfusion related GVHD?
irradiated blood
MC bacteria transmitted through transfusion?
yersinia enterocolitica
transfusion can lead to what of RBC?
hemolysis
MOA hemolysis post transfusion?
inc ROS, inc cytokines
composition of whole blood is deficiency in what?
deficient in clotting factors, contains potassium ammonia and hydrogen ions
serum ab against donor HLA antigens?
febrile non hemolytic transfusion reaction
manifestation of IgA deficiency in transfusion
anaphylactic reaction
lab test positive in acute hemolytic transfusion reaction?
direct coombs
how to prevent CMV transmission in IC during blood transfusion?
leukoreduction
what to do to a transfusion for patient with allergic reactions or IGA deficiency?
washed
how to prevent GVHD in patients during blood transfusion?
Irradiation of blood
