Clotting Flashcards
Polycythemia vera sx?
vertigo, tinnitus, TIA, splenomegaly, clotting, thrombocytosis
EPO in PCV?
decreased
secondary polycythemia EPO level?
increased
causes of secondary Polycythemia?
RCC, OSA, COPD
level of platelet in secondary polycythemia?
not increased
clinical findings of APS?
arterial or venous thrombosis, recurrent pregnancy losses
other symtpoms of APS?
livedo reticularis, migraines, chorea, TIA
Labs for APS?
thrombocytopenia, hemolysis, coombs postivie, B2 glycoprotein, lupus anticoagulant, anticardiolipin
Elevated PTT
treatment of APS?
anticoagulation, steroids, pharesis if MAHA
factor V leiden mutation mechanism?
prevents protein C from braking down coagulation cascade therefor thrombophilic
high risk sites for DVT?
iliac, fem, pop 50% will travel
protein C deficiency genetics?
AD
protein C typically inhibits what?
factor V, VIII
thrombotic complication of PC vera?
mesenteric vein thrombosis
mechanism of polycythemia vera?
Jak2 mutation
how is vitamin K synthesized?
gut bacteria
what can lead to a vitamin K deficiency?
chronic abx use depleting gut bacteria
patients with APS and lupus can have a false positive for what disease?
syphillis (RPR), react with anticardiolipin ab
ATIII deficiency presentation?
AD hypercoagulable disease
resistance to what drug in ATIII deficiency?
heparin- PTT will remain normal because ATIII needed to achieve effect
cryoglobulinemia association?
HCV
cryoglobulinemia labs?
low complement,
cryoglobulinemia presentation
hyperviscosity syndrome
tx for HCV associated cryo?
ribavirin or direct hepatitis meds
