Thrombocytopenia

Question 1

MOA of ITP?

Answer 1

acquired autoab destruction

Question 2

when to tx ITP?

Answer 2

<50000

Question 3

tx for ITP?

Answer 3

steroids, IVIG,, rituxan, splenectomy curative but high mortality

Question 4

what is ADAMTS 13 used for?

Answer 4

protease for cleaving VWF

Question 5

MOA of HIT?

Answer 5

autoab developes complexes with heparin increasing risk for thrombosis

Question 6

anti Pf4 ELISA OD threshold?

Answer 6

> 1 high incidence of HIT

Question 7

differentiate thrombocytopenia in TTP versus sepsis?

Answer 7

TTP no fever

Question 8

plt count in drug induced thrombocytopenia?

Answer 8

<30000

Question 9

drugs that cause thrombocytopenia?

Answer 9

AED, abx, H2 blockers, antiplatelet

Question 10

reduced in DIC?

Answer 10

fibrinogen, factor V, factor VIII

Question 10

reduced in DIC?

Answer 10

fibrinogen, factor V, factor VIII

Question 11

preferred tx of HIT if renal dysfunction?

Answer 11

argatroban

Question 12

4 T of HIT?

Answer 12

timing- 5 to 10 d post ecposure
thrombocytopenia- >50% reduction
other causes ruled out
thrombosis