Leukemia

Question 1

HLH findings?

Answer 1

fever, splenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, hemophagocytosis, high ferritin, high IL-2

Question 2

tx for HLH?

Answer 2

dex plus etoposide, can consider PLEX

Question 3

poor prognostic signs of HLH?

Answer 3

high ferritin, low plt, age >30, underlying lymphoma, male, low albumin

Question 4

APL is a subtype of what cancer?

Answer 4

AML

Question 5

sx of APL?

Answer 5

DIC, auer rods,

Question 6

chromosomal translocation of APL?

Answer 6

15:17

Question 7

tx for APL?

Answer 7

ATRA

Question 8

acute GVHD signs?

Answer 8

macpap rash, diarrhea, abdominal cramping, elevated bilirubin levels

Question 9

timing of acute GVHD post SCT?

Answer 9

within first 100 days

Question 10

rash of GVHD?

Answer 10

starts on neck and torso and will include palms and soles

Question 11

bx of rash for GVHD?

Answer 11

dermis and epidermis with apoptosis at base of crypts

Question 12

skin reactions post HSCT?

Answer 12

CMV(late), GVHD(early)

Question 13

treatment for TLS?

Answer 13

fluids and rasburicase

Question 14

how does rasburicase work?

Answer 14

urate oxidase converting uric acid into water soluble allantoin

Question 15

one electrolyte different from the rest in TLS?

Answer 15

hypocalcemia

Question 16

cancer MC with leukostasis? pathophys?

Answer 16

AML/ obstruct capillary flow and tissue perfusion

Question 17

MC leukemia in adults? age?

Answer 17

AML, 65 yo

Question 18

initial test for AML concern?

Answer 18

smear shows >20% blasts