Trans 3 Connective tissue

Question 1

What are the fixed cells of the connective tissue?

Answer 1

fibroblast, macrophage, adipose cells, mesenchymal cells

Question 2

What are the free cells of the connective tissue?

Answer 2

Lymphocytes, Plasma cells, eosinophils, monocytes, mast cells, basophils, neutrophils

Question 3

What is the principal cell of the connective tissue and its function?

Answer 3

Fibroblast - produces matrix

other characteristics: fusiform, deployed along collagen fibers

Question 4

T/F the fibroblast frequently divides in the normal connective tissue

Answer 4

F

Question 5

The macrophage is derived from what cell

Answer 5

monocyte

Question 6

fixed cell of the connective tissue that has an irregular surface cytoplasm, many vacuoles, large golgi apparatus, RER, SER, mitochondria, secretory vessels and lysosomes

Answer 6

Macrophage

Question 7

macrophage in the connective tissue

Answer 7

histocyte

Question 8

macrophage in the liver

Answer 8

Kupffer cell / Perisinusoidal macrophage

Question 9

macrophage in nervous systems

Answer 9

microglia

Question 10

macrophage in the epidermis

Answer 10

Langerhans cell

Question 11

macrophage in the lungs

Answer 11

alveolar macrophage

Question 12

macrophage in serous cavities

Answer 12

pleural and peritoneal macrophage

Question 13

cells of the mononuclear phagocytotic system in the bone

Answer 13

osteoclast

Question 14

cells of the Mononuclear phagocytotic system in the lamina propria of the intestine and endometrium of the uterus

Answer 14

fibroblast-derived macrophage

Question 15

location of the nucleus in adipose cells

Answer 15

peripheral, appears like a “signet ring”

Question 16

cells that are pluripotent and becomes any type of connective tissue in response to injury / repair

Answer 16

mesenchymal cells

Question 17

shape of mesenchymal cells

Answer 17

fusiform / stellate

Question 18

size and shape of Lymphocytes

Answer 18

7-9um, spherical

Question 19

describe the nucleus of the lymphocyte in terms of size and staining

Answer 19

large, intensely stained

Question 20

3 types of lymphocytes and their functions

Answer 20

T-lymphocyte - cell mediated immunity
B-lymphocyte - for humoral immune system, production of antibodies
NK cells - cell-mediated but nonspecific

Question 21

B-lymphocytes develop into _ cells to produce antibodies

Answer 21

plasma cells

Question 22

function of eosinophils

Answer 22

allergic reaction, parasitic infection, chronic inflammation

Question 23

size of monocytes

Answer 23

9-17um

Question 24

cell w eccentric, bean shaped nucleus and grayish blue cytoplasm

Answer 24

monocyte

Question 25

cells that are precursors of macrophage

Answer 25

monocyte

Question 26

large ovoid w spherical nucleus, cytoplasms w basophilic granules and located in mucous membranes and skin

Answer 26

mast cells

Question 27

what are contained in the granules of mast cells and funciton

Answer 27

histamine, heparin, eosinophilic, chemotactic factor secretion causes hypersensitivity reaction, allergy, anaphylaxis

Question 28

T/F during an allergic reaction, there is a high amount of basophils

Answer 28

T

Question 29

function of adipose cell

Answer 29

stores neutral fats as energy reservoir and for heat production

Question 30

most abundant Glycosaminoglycan

Answer 30

hyaluronic acid

Question 31

components of glycosaminoglycans

Answer 31

hyaluronic acid, dermatan sulfate, chondroitin sulfate, keratan sulfate, heparan sulfate

Question 32

GAG+ core protein =

Answer 32

proteoglycan

Question 33

function of proteoglycans

Answer 33

strength / elasticity

Question 34

3 structural glycoproteins

Answer 34

fibronectin, laminin, thrombospondin

Question 35

which structural glycoprotein is involved in clotting cascade and adhesion of platelets

Answer 35

thrombospondin

Question 36

function of basement membrane

Answer 36

- for physical binding and support of epithelium to the underlying tissue - control of epithelial growth and differentiation - permit flow of nutrients, metabolites and other molecules to and from an epithelium - selective barrier to the passage of molecules from one compartment to another

Question 37

components of the basement membrane

Answer 37

glycosaminoglycan (heparan sulfate) type IV collagen structural glycoproteins

Question 38

most abundant protein in the human | body, representing 30% of its dry weight

Answer 38

collagen

Question 39

collagen is made up of fibrils that are _nm in diameter

Answer 39

75

Question 40

diameter of collagen

Answer 40

1-20um

Question 41

color of collagen when stained w eosin

Answer 41

pink

Question 42

color of collagen when stained w Mallory's

Answer 42

blue

Question 43

color of collagen when stained w Masson's

Answer 43

green

Question 44

Color of collagen when stained w Sirius red

Answer 44

red

Question 45

location of Type I collagen

Answer 45

cartilage and bone

Question 46

location of type II collagen

Answer 46

hyaline cartilage

Question 47

location of type III collagen

Answer 47

surroundings of organs

Question 48

location of type IV collagen

Answer 48

basement membrane

Question 49

nice to know: disease associated w genetic aberrance on collagen formation? they lack type I collagen and are usually seen w blue sclering, loose joints, short stature and sometimes hearing problems

Answer 49

Osteogenesis imperfecta

Question 50

reticular fibers are type _ collagen

Answer 50

3 | tandaan niyo nalang na reTHREEcular fibers

Question 51

reticular fibers appear black using _ stain

Answer 51

Ag stain

Question 52

reticular fibers appear red / orange _ stain

Answer 52

PAS

Question 53

t/f reticular fibers are abundant in smooth muscle covering spleen and liver

Answer 53

t

Question 54

function of reticular fibers

Answer 54

supporting framework

Question 55

elastic fibers stain black / dark blue using _ stain

Answer 55

orcein

Question 56

2 structures of elastic fibers

Answer 56

elastin - central core, contains desmosine and isodesmosine | fibrillin - surrounding

Question 57

function of elastic fibers

Answer 57

response to stretch and distention

Question 58

disease associated w genetic aberrance on elastic fiber formation

Answer 58

Marfan syndrome

Question 59

function of Loose Connective tissue

Answer 59

diffusion of oxygen and nutrients

Question 60

function of irregular connective tissue

Answer 60

strength

Question 61

examples of dense regular connective tissue

Answer 61

tendon, ligaments