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OS 201 Histo Exam 1 > Trans 3 Connective tissue > Flashcards

Trans 3 Connective tissue Flashcards

1
Q

What are the fixed cells of the connective tissue?

A

fibroblast, macrophage, adipose cells, mesenchymal cells

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2
Q

What are the free cells of the connective tissue?

A

Lymphocytes, Plasma cells, eosinophils, monocytes, mast cells, basophils, neutrophils

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3
Q

What is the principal cell of the connective tissue and its function?

A

Fibroblast - produces matrix

other characteristics: fusiform, deployed along collagen fibers

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4
Q

T/F the fibroblast frequently divides in the normal connective tissue

A

F

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5
Q

The macrophage is derived from what cell

A

monocyte

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6
Q

fixed cell of the connective tissue that has an irregular surface cytoplasm, many vacuoles, large golgi apparatus, RER, SER, mitochondria, secretory vessels and lysosomes

A

Macrophage

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7
Q

macrophage in the connective tissue

A

histocyte

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8
Q

macrophage in the liver

A

Kupffer cell / Perisinusoidal macrophage

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9
Q

macrophage in nervous systems

A

microglia

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10
Q

macrophage in the epidermis

A

Langerhans cell

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11
Q

macrophage in the lungs

A

alveolar macrophage

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12
Q

macrophage in serous cavities

A

pleural and peritoneal macrophage

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13
Q

cells of the mononuclear phagocytotic system in the bone

A

osteoclast

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14
Q

cells of the Mononuclear phagocytotic system in the lamina propria of the intestine and endometrium of the uterus

A

fibroblast-derived macrophage

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15
Q

location of the nucleus in adipose cells

A

peripheral, appears like a “signet ring”

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16
Q

cells that are pluripotent and becomes any type of connective tissue in response to injury / repair

A

mesenchymal cells

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17
Q

shape of mesenchymal cells

A

fusiform / stellate

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18
Q

size and shape of Lymphocytes

A

7-9um, spherical

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19
Q

describe the nucleus of the lymphocyte in terms of size and staining

A

large, intensely stained

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20
Q

3 types of lymphocytes and their functions

A

T-lymphocyte - cell mediated immunity
B-lymphocyte - for humoral immune system, production of antibodies
NK cells - cell-mediated but nonspecific

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21
Q

B-lymphocytes develop into _ cells to produce antibodies

A

plasma cells

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22
Q

function of eosinophils

A

allergic reaction, parasitic infection, chronic inflammation

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23
Q

size of monocytes

A

9-17um

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24
Q

cell w eccentric, bean shaped nucleus and grayish blue cytoplasm

A

monocyte

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25
Q

cells that are precursors of macrophage

A

monocyte

26
Q

large ovoid w spherical nucleus, cytoplasms w basophilic granules and located in mucous membranes and skin

A

mast cells

27
Q

what are contained in the granules of mast cells and funciton

A

histamine, heparin, eosinophilic, chemotactic factor

secretion causes hypersensitivity reaction, allergy, anaphylaxis

28
Q

T/F during an allergic reaction, there is a high amount of basophils

A

T

29
Q

function of adipose cell

A

stores neutral fats as energy reservoir and for heat production

30
Q

most abundant Glycosaminoglycan

A

hyaluronic acid

31
Q

components of glycosaminoglycans

A

hyaluronic acid, dermatan sulfate, chondroitin sulfate, keratan sulfate, heparan sulfate

32
Q

GAG+ core protein =

A

proteoglycan

33
Q

function of proteoglycans

A

strength / elasticity

34
Q

3 structural glycoproteins

A

fibronectin, laminin, thrombospondin

35
Q

which structural glycoprotein is involved in clotting cascade and adhesion of platelets

A

thrombospondin

36
Q

function of basement membrane

A
  • for physical binding and support of epithelium to the underlying tissue
  • control of epithelial growth and differentiation
  • permit flow of nutrients, metabolites and other molecules to and from an epithelium
  • selective barrier to the passage of molecules from one compartment to another
37
Q

components of the basement membrane

A

glycosaminoglycan (heparan sulfate)
type IV collagen
structural glycoproteins

38
Q

most abundant protein in the human

body, representing 30% of its dry weight

A

collagen

39
Q

collagen is made up of fibrils that are _nm in diameter

A

75

40
Q

diameter of collagen

A

1-20um

41
Q

color of collagen when stained w eosin

A

pink

42
Q

color of collagen when stained w Mallory’s

A

blue

43
Q

color of collagen when stained w Masson’s

A

green

44
Q

Color of collagen when stained w Sirius red

A

red

45
Q

location of Type I collagen

A

cartilage and bone

46
Q

location of type II collagen

A

hyaline cartilage

47
Q

location of type III collagen

A

surroundings of organs

48
Q

location of type IV collagen

A

basement membrane

49
Q

nice to know: disease associated w genetic aberrance on collagen formation? they lack type I collagen and are usually seen w blue sclering, loose joints, short stature and sometimes hearing problems

A

Osteogenesis imperfecta

50
Q

reticular fibers are type _ collagen

A

3

tandaan niyo nalang na reTHREEcular fibers

51
Q

reticular fibers appear black using _ stain

A

Ag stain

52
Q

reticular fibers appear red / orange _ stain

A

PAS

53
Q

t/f reticular fibers are abundant in smooth muscle covering spleen and liver

A

t

54
Q

function of reticular fibers

A

supporting framework

55
Q

elastic fibers stain black / dark blue using _ stain

A

orcein

56
Q

2 structures of elastic fibers

A

elastin - central core, contains desmosine and isodesmosine

fibrillin - surrounding

57
Q

function of elastic fibers

A

response to stretch and distention

58
Q

disease associated w genetic aberrance on elastic fiber formation

A

Marfan syndrome

59
Q

function of Loose Connective tissue

A

diffusion of oxygen and nutrients

60
Q

function of irregular connective tissue

A

strength

61
Q

examples of dense regular connective tissue

A

tendon, ligaments

OS 201 Histo Exam 1 (5 decks)

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