Trans 3 Connective tissue Flashcards
What are the fixed cells of the connective tissue?
fibroblast, macrophage, adipose cells, mesenchymal cells
What are the free cells of the connective tissue?
Lymphocytes, Plasma cells, eosinophils, monocytes, mast cells, basophils, neutrophils
What is the principal cell of the connective tissue and its function?
Fibroblast - produces matrix
other characteristics: fusiform, deployed along collagen fibers
T/F the fibroblast frequently divides in the normal connective tissue
F
The macrophage is derived from what cell
monocyte
fixed cell of the connective tissue that has an irregular surface cytoplasm, many vacuoles, large golgi apparatus, RER, SER, mitochondria, secretory vessels and lysosomes
Macrophage
macrophage in the connective tissue
histocyte
macrophage in the liver
Kupffer cell / Perisinusoidal macrophage
macrophage in nervous systems
microglia
macrophage in the epidermis
Langerhans cell
macrophage in the lungs
alveolar macrophage
macrophage in serous cavities
pleural and peritoneal macrophage
cells of the mononuclear phagocytotic system in the bone
osteoclast
cells of the Mononuclear phagocytotic system in the lamina propria of the intestine and endometrium of the uterus
fibroblast-derived macrophage
location of the nucleus in adipose cells
peripheral, appears like a “signet ring”
cells that are pluripotent and becomes any type of connective tissue in response to injury / repair
mesenchymal cells
shape of mesenchymal cells
fusiform / stellate
size and shape of Lymphocytes
7-9um, spherical
describe the nucleus of the lymphocyte in terms of size and staining
large, intensely stained
3 types of lymphocytes and their functions
T-lymphocyte - cell mediated immunity
B-lymphocyte - for humoral immune system, production of antibodies
NK cells - cell-mediated but nonspecific
B-lymphocytes develop into _ cells to produce antibodies
plasma cells
function of eosinophils
allergic reaction, parasitic infection, chronic inflammation
size of monocytes
9-17um
cell w eccentric, bean shaped nucleus and grayish blue cytoplasm
monocyte
cells that are precursors of macrophage
monocyte
large ovoid w spherical nucleus, cytoplasms w basophilic granules and located in mucous membranes and skin
mast cells
what are contained in the granules of mast cells and funciton
histamine, heparin, eosinophilic, chemotactic factor
secretion causes hypersensitivity reaction, allergy, anaphylaxis
T/F during an allergic reaction, there is a high amount of basophils
T
function of adipose cell
stores neutral fats as energy reservoir and for heat production
most abundant Glycosaminoglycan
hyaluronic acid
components of glycosaminoglycans
hyaluronic acid, dermatan sulfate, chondroitin sulfate, keratan sulfate, heparan sulfate
GAG+ core protein =
proteoglycan
function of proteoglycans
strength / elasticity
3 structural glycoproteins
fibronectin, laminin, thrombospondin
which structural glycoprotein is involved in clotting cascade and adhesion of platelets
thrombospondin
function of basement membrane
- for physical binding and support of epithelium to the underlying tissue
- control of epithelial growth and differentiation
- permit flow of nutrients, metabolites and other molecules to and from an epithelium
- selective barrier to the passage of molecules from one compartment to another
components of the basement membrane
glycosaminoglycan (heparan sulfate)
type IV collagen
structural glycoproteins
most abundant protein in the human
body, representing 30% of its dry weight
collagen
collagen is made up of fibrils that are _nm in diameter
75
diameter of collagen
1-20um
color of collagen when stained w eosin
pink
color of collagen when stained w Mallory’s
blue
color of collagen when stained w Masson’s
green
Color of collagen when stained w Sirius red
red
location of Type I collagen
cartilage and bone
location of type II collagen
hyaline cartilage
location of type III collagen
surroundings of organs
location of type IV collagen
basement membrane
nice to know: disease associated w genetic aberrance on collagen formation? they lack type I collagen and are usually seen w blue sclering, loose joints, short stature and sometimes hearing problems
Osteogenesis imperfecta
reticular fibers are type _ collagen
3
tandaan niyo nalang na reTHREEcular fibers
reticular fibers appear black using _ stain
Ag stain
reticular fibers appear red / orange _ stain
PAS
t/f reticular fibers are abundant in smooth muscle covering spleen and liver
t
function of reticular fibers
supporting framework
elastic fibers stain black / dark blue using _ stain
orcein
2 structures of elastic fibers
elastin - central core, contains desmosine and isodesmosine
fibrillin - surrounding
function of elastic fibers
response to stretch and distention
disease associated w genetic aberrance on elastic fiber formation
Marfan syndrome
function of Loose Connective tissue
diffusion of oxygen and nutrients
function of irregular connective tissue
strength
examples of dense regular connective tissue
tendon, ligaments
