Tramadol

Question 1

Tramadol MOA

Answer 1

Acts as both a serotonin and norepinephrine reuptake inhibitor
- can lead to serotonin syndrome which can lead to cardiac arrhythmia

Cardiac SE: agitation, palpitations, rhythm abnormalities, conduction defects and cardiac arrest

Question 2

Tramadol SE

Answer 2

• CNS effects (dizziness, sedation, drowsiness, HA, euphoria, anxiety, depression, lack of concentration)
• constipation
• respiratory depression
• seizures
• serotonin syndrome (SSRI, SNRI, TCAs, Triptans, MAOI)
• withdrawal syndrome