toxins + antidotes Flashcards

1
Q

acetominophen

A

N-acetylcysteine (replenishes glutathione)

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2
Q

salicylates

A

NAHCO3 (alkalinizes urine); dialysis

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3
Q

amphetamines (basic)

A

NH4Cl (acidify urine)

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4
Q

acetylcholineterase inhibitors, organophosphates

A

atropine, pralidoxime

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5
Q

antimuscarininc, anticholinergic agents

A

physostigmine salicylate, control hyperthermia

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6
Q

B-blockers

A

glucagon (acts on GPCR, inc. cAMP in cardiac myocytes)

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7
Q

digitalis

A

normalize K+, lidocaine, anti-dig Fab fragments, Mg2+

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8
Q

iron

A

deferoxamine, deferasirox

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9
Q

lead

A

CaEDTA, dimercaprol, succimer, penicillamine

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10
Q

mercury, arsenic, gold

A

dimercaprol, succimer

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11
Q

copper, arsenic, gold

A

penicillamine

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12
Q

cyanide

A

nitrate+thiosulfate, hydroxocobalamin

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13
Q

methemoglobin

A

methylene blue, vitamin C

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14
Q

carbon monoxide

A

100% oxygen, hyperbaric oxygen

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15
Q

methanol, ethylene glycol (antifreeze)

A

fomepizole>ethanol, dialysis

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16
Q

opioids

A

naloxone, naltrexone

17
Q

benzodiazepines

A

flumazenil

18
Q

TCAs

A

NaHCO3 (plasma alkalinization)

19
Q

heparin

A

protamine

20
Q

warfarin

A

Vit K, FFP

21
Q

tPA, streptokinase, urokinase

A

aminocaproic acid

22
Q

theophylline

A

beta=blocker