equations Flashcards
1
Q
filtration fraction
A
GFR/RPF
2
Q
half life
A
(Vd X 0.7)/CL
steady stage concentration is achieved in 4-5 half lives
3
Q
maintenance dose
A
(Cpss X CL)/[bioavailability]
for meds given IV bioavailability=1
4
Q
loading dose
A
(Vc X Cpss)/[bioavailability]
in patients with renal or hepatic failure, the loading dose remains unchanged but the maintenance dose is decreased
