toxidromes

Question 1

Anticholingeric toxidrome symptoms

Answer 1

Tachycardia
Hyperthermia
Urinary retention
Mydriasis
Ileus
Delirium

THUM.ID

Common examples:
–> antihistamines
–> atropine
–> tricyclic antidepressants

mad as a hatter, blind as a bat, red as a beet, hot as a hare, and dry as a bone

Question 2

Patients presenting with cholinergic overdose present with:

Answer 2

• pinpoint pupils
• overactive bowel sounds
• clammy and sweaty

POC

No changes to HR,BP, RR and temp

Question 3

Patients presenting with opioid overdose often present with:

Answer 3

• HR reduced
• RR reduced
• cold
• PINPOINT pupils
• reduced bowel sounds
• dry

Question 4

Challenges with treating opioid overdose

Answer 4

• patients going into withdrawal
• therefore smaller doses given
• naloxone has a short half life —> may need repeat doses

Question 5

Patients presenting with sympathomimetic overdose features:

Answer 5

MATHS

M-mydriasis
A-agitation
T-tachycardia
H-HTN, hyperthermia
S-seizure / sweating