Quick recall 3 Flashcards
Drug options for reducing the risk of relapse in MS
- Natalizumab (IV)
- Ocrelizumab (anti-cd20 monoclonal antibody)
- Fingolimond
- beta interferon
- glatiraemer acetate
Multiple sclerosis: tackling
- Fatigue
- Spasticity
- Bladder dysfunction
- Oscillopsia (visual fields appear to oscillate)
- Fatigue
–> trial of amantadine - Spasticity
–> baclofen and gabapentin
OR –> diazepam, dantrolene and tizanidine
–> physio - Bladder dysfunction
–> significant residual volume: intermittent self catheterisation
–> no significant volume: ACH to improve urinary frequency - Oscillopsia (visual fields appear to oscillate)
The loss of proprioception and vibration sense (dorsal columns) points towards
subacute combined degeneration of the spinal cord
Lip smacking + post-ictal dysphasia are localising features of a
temporal lobe seizure
paediatric Status epilepticus guidelines
- Buccal midazolam / Iv Lorazepam (2 max doses)
- IV lorazepam
- IV levetiracetam, phenytoin or sodium valproate
- RSI , anaesthetics, using thiopental sodium
reflexes and nerve roots
- ankle
- knee
- bicep
- tricep
Ankle - S1-S2
Knee - L3-L4
Bicep - C5-C6
Triceps - C7-C8
Primary Motor Cortex = Motor Sx = Frontal Lobe
Primary Somatosensory Cortex = Sensory Sx = Parietal Lobe
F = Frontal = Fidgetting
P = Parietal = Paraesthesia
Migraine mx: ACUTE
1ST LINE
- oral triptan + nsaid
OR
- oral triptan + paracetamol
If 12-17 years –> nasal triptan?
Migraine mx: prophylaxis
- Propranolol
- Topiramate (avoid in women of childbearing age)
- amitriptylline
10 sessions acupuncture.
Others
- candesaratan
- calcitonin gene related peptide receptor
Mx myasthenia gravis
- Long acting ACH inhibitors
–> PYRIDOSTIGMINE
Autonomic dysreflexia can only occur if the spinal cord injury occurs above the
T6 level
The combination of severe hypertension, flushing and sweating without a congruent response in heart rate in the context of spinal cord injury indicates an autonomic dysreflexia
Cushing’s triad:
widening pulse pressure
bradycardia
irregular breathing
treatment of choice for essential tremor
Propranolol
resting tremor is seen in parkinsons and this is managed with co-careldopa
this characteristically presents with sensorineural deafness and congenital cataracts.
Rubella!
Rubella the sensitive cat
This may also be associated with cerebral palsy, anaemia, and jaundice. Also is associated with congenital sensorineural deafness
Congenital cytomegalovirus infection
Primary amenorrhoea, little or no axillary and pubic hair, elevated testosterone →
androgen insensitivity syndrome
- bilateral lower pelvic swellings likely to be undescended testes
Alzheimer’s disease causes widespread cerebral atrophy mainly involving the:
cortex and hippocampus