Toxicology of MSK drugs

Question 1

What is the main reason for GI disturbances when taking methotrexate (look up structure)?
a. it inhibits DHFR
b. it contains basic functional groups
c. It is structurally similar to folic acid
d. It contains acidic functional groups

Answer 1

d. It contains acidic functional groups

Question 2

Which of the following statements about the mode of action of methotrexate when used to treat rheumatoid arthritis is incorrect?
a. It is a folic acid antagonist
b. It causes adenosine levels in the blood to rise
c. it inhibits DHFR
d. It causes vasodilation

Answer 2

c. it inhibits DHFR

Question 3

Methotrexate can cause liver toxicity. Which of the following statements about this type of toxicity is incorrect?
a. It is caused by inhibition of AICAR
b. Patients taking methotrexate must have their liver function monitored
c. It is driven by increasing adenosine levels
d. It only occurs when methotrexate is used as an anti-metabolite

Answer 3

d. It only occurs when methotrexate is used as an anti-metabolite

Question 4

Which of the following statements is incorrect about methotrexate therapy?
a. Pregnant women should not take methotrexate
b. It is safe to drink alcohol whilst taking methotrexate
c. Children are at an increased risk of methotrexate toxicity
d. Elderly patients are at an increased risk of toxicity due to reduced liver function

Answer 4

b. It is safe to drink alcohol whilst taking methotrexate