Toxicology of CNS drugs Flashcards
Which of the following statements is INCORRECT about respiratory depression?
a. It causes a build up of CO2 in the blood
b. It causes a decrease in heart rate
c. It can cause cyanosis
d. It occurs when a patient’s breathing is too slow and shallow
e. It causes headaches and tiredness
b. It causes a decrease in heart rate
Which of the following statements about benzodiazepines is INCORRECT?
a. They act as antagonists of the GABA receptors
b. They physiological effect results in a reduction in anxiety, muscle spasms and sedation
c. They are potentially psycho-active at higher doses
d. They cause an increase in the flow of chloride ions through a membrane ion channel
e. Their action prevents re-polarisation of the neuron
a. They act as antagonists of the GABA receptors
Which of the following statements about opioids is INCORRECT?
a. Agonist work by enhancing potassium levels, whilst decreasing calcium level in the neurotransmitter
b. Agonists causes sedation
c. Opioid overdose can be treated with opioid antagonists
d. All agonist act on the same opioid receptors
e. There are three key opioid receptors - Mu, Delta and Kappa
d. All agonist act on the same opioid receptors
NOTE: Not all drugs agonists act on the same receptor. For example, codeine acts on the Mu and Delta receptors, whilst morphone only acts on the delta receptor
Which of the following statements is INCORRECT?
a. Opioid antagonists can be administered in the event of a benzodiazepine/opioid overdose
b. When taken together benzodiazepines enhance the effect of opioids
c. Benzodiazepines enhance opioid metabolism
d. Taking benzodiazepines and opioids together increases the risk of respiratory depression
c. Benzodiazepines enhance opioid metabolism
Which of the following statements is INCORRECT about benzodiazepines and opioid metabolism?
a. Methadone is metabolised into its active form by CYP3A4
b. Diazepam is metabolised into its active form by CP3A4
c. Oxymorphone is metabolised into its inactive form by CYP3A4
d. Oxycodone is metabolised into its active form by CYP2D6
a. Methadone is metabolised into its active form by CYP3A4
