Toxicology (Drug of Abuse)

Question 1

True/ False

STATEMENT I: Almost all drugs of abuse are basic drugs (amine derivatives) which contain benzene rings
STATEMENT II - barbiturates are acidic drugs

Answer 1

Both are True

Question 2

therapeutically used for treatment of narcolepsy and attentional deficit disorder
-increases mental alertness and physical capacity

Answer 2

Amphetamines

Question 3

causes false-positive reaction for amphetamines

Answer 3

presence of antihistamine

Question 4

a popular recreational abused drug that has a psychedelic effects

Answer 4

3,4-methylenedioxymethamphetamine or MDMA or ‘ectasy’

Question 5

improves athletic performance by increasing muscle mass

Answer 5

anabolic steroids

Question 6

what are the naturally occurring cannabinoids

Answer 6

Marijuana
hashish

Question 7

the most potent component or the psychoactive substance of marijuana

Answer 7

Tetrahydrocannabinol (THC)

Question 8

after a single use, THC-COOH can be detected in urine for ______; up to _____ for chronic user

Answer 8

3-5 days, 4 weeks

Question 9

what is the principal psychoactive agent of cannabinoids

Answer 9

delta-9-tetrahydrocannabinol

Question 10

urinary metabolite for cannabinoids

Answer 10

11-nor-deltatetrahydrocannabinol (THC-COOH)

Question 11

its is derived from coca plant (Erythroxylon) and use as additive to some foods
-used as local anesthetic for nasopharyngeal surgery

Answer 11

cocaine (crack)

Question 12

treatment for cocaine addiction

Answer 12

benzodiazepine

Question 13

for single use of cocaine, it can be detected in urine ____; up to _____ for chronic user

Answer 13

3 days, 20 days

Question 14

what are the naturally occurring opiates

Answer 14

Opium
morphine
codeine

Question 15

it is a nonbicyclic drug that binds with morphine in the brain

Answer 15

Methadone

Question 16

Antagonist for Opiate overdose

Answer 16

Naloxone

Question 17

it is an antitussive drug

Answer 17

Codeine

Question 18

it crosses the blood-brain barrier - elevated levels in the CNS

Answer 18

Heroin

Question 19

it is a depressant, stimulant, and has a hallucinogenic an anaesthetic properties
-Mode of Treatment : Isolation

Answer 19

Phencyclidine (angel dust or angel hair)

Question 20

they have therapeutic roles and they are CNS depressants
they are used also to potentiate the effects of heroin

Answer 20

Sedative Hypnotics

Question 21

Common adverse reaction : Panic reaction “bad trip”
one of the most potent pharmacologic materials known

Answer 21

Lysergic Acid diethylamide

Question 22

it is a 2,3-disubstituted quinazoline with anaesthetic, antihistamine and antitussive properties
pyramidal signs (Hypertonicity, hyperreflexia and myoclonus)

Answer 22

Methaqualone (Quaalude)

Question 23

they produces the same “pleasant feeling” observed in amphetamines

Answer 23

Piperazines

Question 24

these are derivatives of serotonin ; compounds present in plants

Answer 24

tryptamines

Question 25

it is a short-term hallucinogen (“businessman’s lunch”; taken by smoking

Answer 25

dimethyltryptamines (DMT)

Question 26

is a component of “magic mushrooms” (psilocybe); a hallucinogen

Answer 26

Psilocycin

Question 27

is a tea which contains tryptamines

Answer 27

Ayahuasca

Question 28

2 basic techniques for identification of drugs

Answer 28

Immunochemical
chromatography