PROTEIN

Question 1

-serves as a transport for T4 and retinol
-used to detect malnutrition
-landmark to confirm that the specimen is really CSf

Answer 1

Prealbumin (transthyretin)

Question 2

-most anodal protein
-major contributor to oncotic colloidal pressure

Answer 2

Albumin

Question 3

• an acute phase reactant
  -major inhibitor of protease

Answer 3

Alpha1- antitrypsin

Question 4

-the most abundant protein in in fetal serum
-peaks in the fetus at 13 weeks of gestation
-no known function in adult

Answer 4

Alpha1- fetoprotein

Question 5

-negatively charge even in acid solution
-greatest affinity for progesterone
-useful diagnostic tool in neonates with bacterial infections

Answer 5

A1- Acid Glycoprotein/orosomucoid (AAG)

Question 6

-acute phase reactant
-major form of PSA found in human sera
-associated with ALZHEIMERS DISEASE

Answer 6

A1- antichymotrypsin

Question 7

-acute phase reactant
-it binds free hemoglobin by is A chain
-evaluates degree of intravascular hemolysis (HTR & HDN)
-one of the proteins used to evaluate rheumatic diseases

Answer 7

Haptoglobin

Question 8

• it is a copper-binding a2 glycoprotein
  -imparts BLUE color to protein
  -marker for WILSON’S DISEASE and cornea (KAYSER-FISHER RINGS)

Answer 8

Ceruloplasmin

Question 9

-largest major nonimmunoglobulin protein in plasma
-inhibits proteases such as trypsin, pepsin and plasmin

Answer 9

a2- Macroglobulin

Question 10

-light chain component of the major HUMAN LEUKOCYTE ANTIGEN (HLA)
-freely filtered at the glomerulus but reabsorbed

Answer 10

b2- Microglobulin

Question 11

-major component of B2-globulin fraction
-it transport iron to its storage site; CSF contain small amount
-PSUEDOPARAPROTEINEMIA in severe iron deficiency anemia
-increased: hemochromatosis (bronze-skin), IDA

Answer 11

TRANSFERRIN (siderophilin)

Question 12

-synthesized in the plasma cells
-igG, IgA, IgM, IgD, IgE

Answer 12

Immunoglobulins

Question 13

-binds with protein and lipids forming LDL, HDL, VLDL
-transport TAG and phospholipids

Answer 13

Lipoprotein

Question 14

-one of the largest protein in the blood
-most abundant of the coagulation factor
-markedly increase in inflammatory process
-serve as a marker for long-term prognosis of cardiovascular disease

Answer 14

Fibrinogen

Question 15

-one of the natural defense mechanisms that protects the human body from infection

Answer 15

COMPLEMENT

Question 16

the most abundant form in serum-it is also important in the pathogenesis of age-related macular degeneration

Answer 16

C3

Question 17

it is a convenient marker for assessing disease activity in rheumatic disorder such as RA and SLE

Answer 17

C3 and C4

Question 18

-member of pentraxin family
-appears in the blood of the patients with diverse inflammatory disease
-it is an inflammatory marker
-undetectable in the blood of healthy individual

Answer 18

C-reactive protein

Question 19

-it is a small heme protein found in skeletal and cardiac muscle
-transport and stored oxygen form hemoglobin
-higher affinity for oxygen than does hemoglobin

Answer 19

Myoglobin

Question 20

-these are regulators of actin and myosin
-these are complex of three protein
-most important marker of cardiac injury

Answer 20

Troponins

Question 21

valuable tool in the diagnosis of AMI
-useful for assessment of early and late AMI; elevated in renal disease and muscular dystrophy

Answer 21

Troponin T

Question 22

-it is only found in the myocardium -greater cardiac marker than TnT
-highly specific for AMI

Answer 22

Troponin I

Question 23

-cardiac marker
-increases in response to peptide ventricular systolic and diastolic dysfunction and is diagnostic of congestive heart failure

Answer 23

BNP