Toxicology Flashcards
What is the number for the poison control center?
1-800-222-1222
What are the important aspects when determining toxicity?
- what was ingested
- when and how much was ingested
- other non-drug ingestions
What are the general treatments for all toxicology?
- crystalloid fluids
- activated charcoal (1-2h of ingestion)
- HD
What are s/s of anticholinergic toxicity?
- confusion
- tachycardia
- decreased urine output
- dry mouth
- flushed skin
- dilated pupils
What agents cause anticholinergic toxicity?
- antihistamines
- TCAs
- SSRIs
- antipsychotics
- muscle relaxants
- H2RAs
What are the common causes of cholinergic toxicity?
- organophaoshates
- pyridostigmine
What are s/s of sympathomimetic toxicity?
- agitation
- mydriasis
- tachycardia, HTN
- hyperthermia, diaphoresis
What doses of Tylenol are considered toxic?
- > 7.5 g in adults
- > 150mg/kg in children
What are the outcomes of congestion of ethanol with Tylenol?
can be protective and or harmful, ethanol inhibits CYP2E1
What is the toxic metabolite of Tylenol?
NAPQI
What must be true of Tylenol ingestion to use Rumack Matthew Nomogram?
- must be IR product
- acute, single-dose ingestion
- between 4 and 24 hours after ingestion
How is Tylenol ingestion treated if Rumack Matthew Nomogram cannot be used?
treat if signs of liver damage (AST, ALT. T.bili, INR)
What is the dosing of IV NAC for tylenol toxicity?
150 mg/kg over 1 h
50 mg/kg over 4 hours
100 mg/kg over the next 16h
What is the dosing of PO NAC for tylenol toxicity?
140 mg/kg loading dose
70 mg/kg orally every 4 h
Total of 18 doses in 72 h
What are s/s of aspirin toxicity?
Triad of hyperventilation, tinnitus, GI irritation
