Toxicity and Side Effects I

Question 1

acetaminophen OD

Answer 1

N-acetylcysteine - replenish glutathione

Question 2

AChE inhibitor or organophosphate OD

Answer 2

atropine > pralidoxime

Question 3

amphetamine OD

Answer 3

amphetamines are basic

-to NH4Cl - to acidify urine

Question 4

anticholinergic OD

Answer 4

physostigmine salicylate - control hyperthermia

Question 5

benzo OD

Answer 5

flumazenil

Question 6

beta-blocker OD

Answer 6

glucagon

Question 7

carbon monoxide OD

Answer 7

100% O2

Question 8

Cu OD

Answer 8

penicillamine

Question 9

arsenic OD

Answer 9

penicillamine

Question 10

gold OD

Answer 10

penicillamine

Question 11

CN OD

Answer 11

nitrite and thiosulfate

hydroxocobalamin

Question 12

digitalis OD

Answer 12

anti-dig Fab fragment

Question 13

heparin OD

Answer 13

protamine sulfate

Question 14

iron OD

Answer 14

deferoxamine

deferasirox

Question 15

Pb OD

Answer 15

EDTA
dimercaprol
succimer
pencilliamine

Question 16

mercury OD

Answer 16

dimercaprol (BAL), succimer

Question 17

methanol OD

Answer 17

fomepizole
ethanol
dialysis

Question 18

methemoglobin tx

Answer 18

methylene blue

vit C

Question 19

opioid OD

Answer 19

naloxone

naltrexone

Question 20

salicylate OD

Answer 20

NaHCO3

-alkalinize urine

Question 21

TCA OD

Answer 21

NaHCO3

-alkalinize plasma

Question 22

tPA OD

Answer 22

aminocaproic acid

Question 23

warfarin OD

Answer 23

vit K - delayed effect

fresh frozen plasma - immediate effect

Question 24

doxorubicine adverse tx

Answer 24

dexrazoxane

Question 25

torsades causes

Answer 25

class III and Ia antiarrhythmic macrolides antipsychotics TCAs

Question 26

HPA suppression

Answer 26

rapid withdrawal glucocorticoids

Question 27

hot flashes

Answer 27

with tamoxifen and clomiphene

Question 28

hyperglycemia

Answer 28

``` with tacrolimus protease inhibitor niacin HCTZ corticosteroids ```

Question 29

hypothyrodism

Answer 29

with lithium amiodarone sulfonamides

Question 30

focal to massive hepatic necrosis

Answer 30

with halothane amanita phalloides - death cap mushroom valproic acid acetaminophen

Question 31

drugs cause hepatitis

Answer 31

``` rifampin isoniazid pyrazinamide statin fibrate ```

Question 32

drug cause pancreatitis

Answer 32

``` didanosine corticosteroid alcohol valproic acid azathioprine diuretic ```

Question 33

drugs cause pseudomembranous colitis

Answer 33

predispose - C. dif infection clindamycin ampicillin cephalosporins

Question 34

drugs cause agranulocytosis

Answer 34

``` gangciclovir clozapine carbamazepine colchicine methimazole PTU ```

Question 35

drugs cause aplastic anemia

Answer 35

``` carbamazepine methomazole NSAID benzene chloramphenicol PTU ```

Question 36

drug cause gray baby syndrome

Answer 36

cholramphenicol

Question 37

thrombocytopenia adverse

Answer 37

heparin

Question 38

thrombotic complication drugs

Answer 38

OCPs | hormone replacement

Question 39

hemolysis in G6PD drugs

Answer 39

``` isoniazid sulfonamides dapsone primaquine ASA ibuprofen nitrofurantoin ```

Question 40

fat redistribution drugs

Answer 40

protease inhibitor | glucocorticoids

Question 41

gingival hyperplasia

Answer 41

phenytoin CCBs cyclosporin

Question 42

gout drugs

Answer 42

``` pyrazinamide thiazide furosemide niacin cyclosporine ```