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Board Review - B - Pharmacology > Toxicity and Side Effects I > Flashcards

Toxicity and Side Effects I Flashcards

1
Q

acetaminophen OD

A

N-acetylcysteine - replenish glutathione

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2
Q

AChE inhibitor or organophosphate OD

A

atropine > pralidoxime

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3
Q

amphetamine OD

A

amphetamines are basic

-to NH4Cl - to acidify urine

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4
Q

anticholinergic OD

A

physostigmine salicylate - control hyperthermia

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5
Q

benzo OD

A

flumazenil

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6
Q

beta-blocker OD

A

glucagon

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7
Q

carbon monoxide OD

A

100% O2

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8
Q

Cu OD

A

penicillamine

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9
Q

arsenic OD

A

penicillamine

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10
Q

gold OD

A

penicillamine

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11
Q

CN OD

A

nitrite and thiosulfate

hydroxocobalamin

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12
Q

digitalis OD

A

anti-dig Fab fragment

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13
Q

heparin OD

A

protamine sulfate

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14
Q

iron OD

A

deferoxamine

deferasirox

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15
Q

Pb OD

A

EDTA
dimercaprol
succimer
pencilliamine

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16
Q

mercury OD

A

dimercaprol (BAL), succimer

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17
Q

methanol OD

A

fomepizole
ethanol
dialysis

18
Q

methemoglobin tx

A

methylene blue

vit C

19
Q

opioid OD

A

naloxone

naltrexone

20
Q

salicylate OD

A

NaHCO3

-alkalinize urine

21
Q

TCA OD

A

NaHCO3

-alkalinize plasma

22
Q

tPA OD

A

aminocaproic acid

23
Q

warfarin OD

A

vit K - delayed effect

fresh frozen plasma - immediate effect

24
Q

doxorubicine adverse tx

A

dexrazoxane

25
Q

torsades causes

A

class III and Ia antiarrhythmic
macrolides
antipsychotics
TCAs

26
Q

HPA suppression

A

rapid withdrawal glucocorticoids

27
Q

hot flashes

A

with tamoxifen and clomiphene

28
Q

hyperglycemia

A 
with tacrolimus
protease inhibitor
niacin
HCTZ
corticosteroids
29
Q

hypothyrodism

A

with lithium
amiodarone
sulfonamides

30
Q

focal to massive hepatic necrosis

A

with halothane
amanita phalloides - death cap mushroom
valproic acid
acetaminophen

31
Q

drugs cause hepatitis

A 
rifampin
isoniazid
pyrazinamide
statin
fibrate
32
Q

drug cause pancreatitis

A 
didanosine
corticosteroid
alcohol
valproic acid
azathioprine
diuretic
33
Q

drugs cause pseudomembranous colitis

A

predispose - C. dif infection

clindamycin
ampicillin
cephalosporins

34
Q

drugs cause agranulocytosis

A 
gangciclovir
clozapine
carbamazepine
colchicine
methimazole
PTU
35
Q

drugs cause aplastic anemia

A 
carbamazepine
methomazole
NSAID
benzene
chloramphenicol
PTU
36
Q

drug cause gray baby syndrome

A

cholramphenicol

37
Q

thrombocytopenia adverse

A

heparin

38
Q

thrombotic complication drugs

A

OCPs

hormone replacement

39
Q

hemolysis in G6PD drugs

A 
isoniazid
sulfonamides
dapsone
primaquine
ASA
ibuprofen
nitrofurantoin
40
Q

fat redistribution drugs

A

protease inhibitor

glucocorticoids

41
Q

gingival hyperplasia

A

phenytoin
CCBs
cyclosporin

42
Q

gout drugs

A 
pyrazinamide
thiazide
furosemide
niacin
cyclosporine

Board Review - B - Pharmacology (7 decks)

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