Autonomic Drugs I Flashcards
adrenal medulla and sweat glands
sympathetic
-but innervated by cholinergic
botulinum
prevent release of ACh at cholinergic terminals
nAChR mechanism
ligand gated
-Na/K channels
Nn - autonomic ganglia
Nm - at NMJ
NMJ receptor
nAChR
adrenal medulla receptor
nAChR
sweat gland receptor
mAChR - postganglionic - sympathetic
parasympathetic receptors
nAChR - preganglionic
mAChR - postganglionic
sympathetic to renal vasc smooth muscle receptors
pregang - nAChR
postgang - D1
mAChR mechanism
GPCRs - act through 2nd messengers
5 subtypes - M1-M5
sympathetic receptors
pregang - nAChR
postgang - alpha/beta adrenergic - NE
all preganglionic
nAChR
alpha1 receptor type
GPCR q
alpha1 receptor function
vasc smooth m contraction
pupil dilator m contraction (mydriasis)
increased intestinal and bladder sphincter contraction
alpha2 receptor type
GPCR i
alpha2 receptor function
decreased sympathetic outflow decreased insulin release decreased lipolysis increased platelet aggregation decreased aqueous humor production
beta1 receptor type
GPCR s
beta1 receptor function
increased HR
increased contractility
increased renin release
increased lipolysis
beta2 receptor type
GPCR s
beta2 receptor function
vasodilation bronchodilation increased lipolysis increased insulin release decreased uterine tone (tocolysis) ciliary muscle relaxation increased aqueous humor production
M1 receptor type
GPCR q
M1 receptor function
CNS, enteric nervous system
M2 receptor type
GPCR i
M2 receptor function
decreased heart rate
contraction of atria
M3 receptor type
GPCR q
M3 receptor function
exocrine gland secretion - lacrimal, salivary, gastric acid
increased gut peristalsis
increased bladder contraction
bronchoconstriction
pupillary sphincter contraction - miosis
ciliary muscle contraction - accomodation
D1 receptor type
GPCR s
D1 receptor function
relax renal vasc smooth m
D2 receptor type
GPCR i
D2 receptor function
modulate transmitter release - in brain
H1 receptor type
GPCR q
H1 receptor function
nasal and bronchial mucus production increased vasc permeability contraction bronchioles pruritis pain
H2 receptor type
GPCR s
H2 receptor function
increased gastric acid secretion
V1 receptor type
GPCR q
V1 receptor function
increased vasc smooth m contraction
V2 receptor type
GPCR s
V2 receptor function
increased H2O permeability CT of kidney
GPCR q function
activate phospholipase C
-cleave PIP2 > IP3 and DAG
DAG > protein kinase C
IP3 > increased Ca - smooth m contraction
GPCR s function
activate adenylyl cyclase
-ATP to cAMP
cAMP - activate protein kinase A
protein kinase A - increased Ca in heart
inhibit myosin light chain kinase smooth m
GPCR i function
inhibit adenylyl cyclase
-less ATP to cAMP
less protein kinase A
less Ca in heart
disinhibit myosin light chain kinase smooth m
QISS and QIQ til you’re SIQ of SQS
Q - alpha1
I - alpha2
S - beta1
S - beta2
Q - M1
I - M2
Q - M3
S - D1
I - D2
Q - H1
S - H2
Q - V1
S - V2
