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Board Review - B - Pharmacology > Autonomic Drugs I > Flashcards

Autonomic Drugs I Flashcards

1
Q

adrenal medulla and sweat glands

A

sympathetic

-but innervated by cholinergic

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2
Q

botulinum

A

prevent release of ACh at cholinergic terminals

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3
Q

nAChR mechanism

A

ligand gated
-Na/K channels

Nn - autonomic ganglia
Nm - at NMJ

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4
Q

NMJ receptor

A

nAChR

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5
Q

adrenal medulla receptor

A

nAChR

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6
Q

sweat gland receptor

A

mAChR - postganglionic - sympathetic

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7
Q

parasympathetic receptors

A

nAChR - preganglionic

mAChR - postganglionic

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8
Q

sympathetic to renal vasc smooth muscle receptors

A

pregang - nAChR

postgang - D1

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9
Q

mAChR mechanism

A

GPCRs - act through 2nd messengers

5 subtypes - M1-M5

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10
Q

sympathetic receptors

A

pregang - nAChR

postgang - alpha/beta adrenergic - NE

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11
Q

all preganglionic

A

nAChR

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12
Q

alpha1 receptor type

A

GPCR q

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13
Q

alpha1 receptor function

A

vasc smooth m contraction
pupil dilator m contraction (mydriasis)
increased intestinal and bladder sphincter contraction

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14
Q

alpha2 receptor type

A

GPCR i

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15
Q

alpha2 receptor function

A 
decreased sympathetic outflow
decreased insulin release
decreased lipolysis
increased platelet aggregation
decreased aqueous humor production
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16
Q

beta1 receptor type

A

GPCR s

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17
Q

beta1 receptor function

A

increased HR
increased contractility
increased renin release
increased lipolysis

18
Q

beta2 receptor type

A

GPCR s

19
Q

beta2 receptor function

A 
vasodilation
bronchodilation
increased lipolysis
increased insulin release
decreased uterine tone (tocolysis)
ciliary muscle relaxation
increased aqueous humor production
20
Q

M1 receptor type

A

GPCR q

21
Q

M1 receptor function

A

CNS, enteric nervous system

22
Q

M2 receptor type

A

GPCR i

23
Q

M2 receptor function

A

decreased heart rate

contraction of atria

24
Q

M3 receptor type

A

GPCR q

25
Q

M3 receptor function

A

exocrine gland secretion - lacrimal, salivary, gastric acid
increased gut peristalsis
increased bladder contraction
bronchoconstriction
pupillary sphincter contraction - miosis
ciliary muscle contraction - accomodation

26
Q

D1 receptor type

A

GPCR s

27
Q

D1 receptor function

A

relax renal vasc smooth m

28
Q

D2 receptor type

A

GPCR i

29
Q

D2 receptor function

A

modulate transmitter release - in brain

30
Q

H1 receptor type

A

GPCR q

31
Q

H1 receptor function

A 
nasal and bronchial mucus production
increased vasc permeability
contraction bronchioles
pruritis
pain
32
Q

H2 receptor type

A

GPCR s

33
Q

H2 receptor function

A

increased gastric acid secretion

34
Q

V1 receptor type

A

GPCR q

35
Q

V1 receptor function

A

increased vasc smooth m contraction

36
Q

V2 receptor type

A

GPCR s

37
Q

V2 receptor function

A

increased H2O permeability CT of kidney

38
Q

GPCR q function

A

activate phospholipase C
-cleave PIP2 > IP3 and DAG

DAG > protein kinase C
IP3 > increased Ca - smooth m contraction

39
Q

GPCR s function

A

activate adenylyl cyclase
-ATP to cAMP

cAMP - activate protein kinase A

protein kinase A - increased Ca in heart
inhibit myosin light chain kinase smooth m

40
Q

GPCR i function

A

inhibit adenylyl cyclase
-less ATP to cAMP

less protein kinase A
less Ca in heart
disinhibit myosin light chain kinase smooth m

41
Q

QISS and QIQ til you’re SIQ of SQS

A

Q - alpha1
I - alpha2
S - beta1
S - beta2

Q - M1
I - M2
Q - M3

S - D1
I - D2
Q - H1

S - H2
Q - V1
S - V2

Board Review - B - Pharmacology (7 decks)

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