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Board Review - B - Pharmacology > Autonomic Drugs III > Flashcards

Autonomic Drugs III Flashcards

1
Q

atropine MOA

A

muscarinic antagonist

used to tx bradycardia
and for ophthalmic applications

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2
Q

affects of atropine

A 
eye - pupil dilation and cycloplegia (paralysis eye mm)
airway - decreased secretion
stomach - decreased acid secretion
gut - decreased motility
bladder - decreased urgency
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3
Q

atropine toxicity

A 
hot as hare
dry as bone
red as beet
blind as bat
mad as hatter
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4
Q

increased body temp, rapid pulse, dry pulse, dry flushed skin, cycloplegia, constipation, disorientation

A

atropine toxicity

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5
Q

tetrodotoxin

A

binds fast voltage gated Na channels - cardiac and nerve tissues

prevents depolarization

nausea, dizziness, paresthesias, weakness, loss of reflexes

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6
Q

poorly prepared pufferfish

A

tetrodotoxin

binds fast voltage gated Na channels cardiac and nerve tisue

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7
Q

ciguatoxin

A

fish poisoning - consumption of reef fish - barracuda, snapper, moray eel

opens Na channels - depolarization

temp dysesthesia - cold feels hot, hot feels cold**

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8
Q

scombroid poisoning

A

acute onset - burning sensation of moth, flushing face, erythema, urticaria, pruritis, headache

consumption of dark meat fish - bonito, mackeral, mahi-mahi, tuna - stored at warm temp

bacterial histidine decarboxylase - converts histidine to histamine

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9
Q

albuterol

A

beta2 > beta1 agonist

acute asthma

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10
Q

salmeterol

A

beta2 > beta1 agonist

long term asthma

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11
Q

dobutamine

A

beta1 > beta2, a agonist

HF

cardiac stress testing

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12
Q

dopamine

A

D1 = D2 > B > a
agonist

inotropic and chronotropic - at high doses

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13
Q

epinephrine

A

B > a
agoinst

anaphylaxis
asthma
open angle glaucoma

a - at high doses

and stronger B2 effect

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14
Q

isoproterenol

A

non-selective B agonist

B1 = B2

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15
Q

norepinephrine

A

a1 > a2 > B1 agonist

tx hypotension
weak at B2

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16
Q

phenylephrine

A

a1 > a2 agonist

hypotension

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17
Q

amphetamine

A

sympathomimetic indirect

indirect general agonist - reuptake inhibitor

18
Q

cocaine

A

agnonist sympathetic

reuptake inhibitor

19
Q

CI with cocaine intox

A

beta-blocker

-unopposed a1 activation - extreme hypertension

20
Q

ephedrine

A

general sympathetic agonist

release stored catecholamines

21
Q

NE vs. isoproterenol

A

NE - a1 vasoconstriction
iso - B2 vasodilation

NE - increased MAP - reflex bradycardia

iso - decreased MAP - increased HR - reflex tachy

22
Q

clonidine

A

a2 agonist

23
Q

a-methyldopa

A

a2 agonist

tx HTN in pregnancy

24
Q

phenoxybenzamine

A

irreversible a-blocker

tx of pheochromocytoma
-preop - prevent HTN crisis

25
Q

phentolamine

A

reversible a-blocker

tx of tyramine MAO interaction

26
Q

prazosin

A

a1 antagonist

27
Q

terazosin

A

a1 antagonist

28
Q

doxazosin

A

a1 antagonist

29
Q

tamsulosin

A

a1 antagonist

30
Q

tx PTSD

A

prazosin - a1 blocker

31
Q

tx of BPH urinary sx

A

a1 blocker - prazosin

32
Q

mirtazapine

A

a2 blocker

tx of depression

33
Q

phenylephrine vs. epinephrine

A

E - a and B agoinst
P - only a-agonist

when give phentolamine - a block

  • E - reversal of MAP - B effect
  • P - suppression, not reversal of MAP - bc only a
34
Q

tx of SVT

A 
metoprolol and esmolol
-class II antiarrhythmic
35
Q

glaucoma tx

A

timolol - beta blocker - decreased aqueous humor production

36
Q

B1 on kidney

A

increased renin secretion

beta-blocker - block this

37
Q

beta1 selective antagonists

A

acebutolol, atenolol, betaxolol, esmolol, metoprolol

A > M

38
Q

non-selective beta antagonists

A

nadolol, pindolol, timolol, propanolol

N > Z

39
Q

cardevilol

A

a and B antagonist

40
Q

labetalol

A

a and B antagonist

41
Q

nebivolol

A

combine B1 block with B3 stimulation - activate nitric oxide synthase in vasculature

Board Review - B - Pharmacology (7 decks)

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