Autonomic Drugs II

Question 1

hemicholinium MOA

Answer 1

block choline reuptake to cholinergic neurons

Question 2

vesamicol MOA

Answer 2

block ACh uptake into storage vesicles in cholinergic neurons

Question 3

botulinum MOA

Answer 3

block vesicular fusion of ACh vesicles with presynaptic membrane

Question 4

AChE inhibitor MOA

Answer 4

block breakdown of ACh in synaptic cleft

Question 5

metyrosine MOA

Answer 5

block tyrosine > DOPA

in noradrenergic nerve

Question 6

reserpine MOA

Answer 6

block dopamine uptake into vesicles

in noradrenergic nerve

Question 7

bretylium MOA

Answer 7

block NE release from noradrenergic nerves

Question 8

guanethidine MOA

Answer 8

block NE release from noradrenergic nerves

Question 9

amphetamine MOA

Answer 9

increase NE release from noradrenergic nerves

AND inhibit NE reuptake

Question 10

ephedrine MOA

Answer 10

increased NE release from noradrenergic nerves

Question 11

cocaine MOA

Answer 11

decreased reuptake of NE

Question 12

TCA MOA

Answer 12

decreased reuptake of NE

Question 13

NE negative feedback

Answer 13

to alpha2 on presynaptic autoreceptors

blocks release of more NE

Question 14

AT2 receptor

Answer 14

activation leads to more NE release

Question 15

bethanecol drug type

Answer 15

cholinomimetic

resistant to AChE

Question 16

carbachol drug type

Answer 16

cholinomimetic

Question 17

methacholine drug type

Answer 17

cholinomimetic

Question 18

pilocarpine drug type

Answer 18

cholinomimetic

resistant to AChE

Question 19

drug challenge test for asthma

Answer 19

methacholine

Question 20

tx postop ileus, neurogenic ileus, urinary retention

Answer 20

bethanechol

Question 21

drug constrict pupil and relieve intraocular P in glaucoma

Answer 21

carbachol

Question 22

drug stimulate seat, tears, saliva

tx open and closed angle glaucoma

Answer 22

pilocarpine

closed angle - pupillary sphincter
open angle - ciliary m of eye

Question 23

donepezil

Answer 23

AChE inhibitor

tx of AD

Question 24

galantamine

Answer 24

AChE inhibitor

tx of AD

Question 25

rivastigmine

Answer 25

AChE inhibitor | tx of AD

Question 26

edrophonium

Answer 26

AChE inhibitor old diagnosis of myasthenia gravis - would improve sx new test - anti-ACh receptor Ab

Question 27

neostigmine

Answer 27

AChE inhibitor -no CNS penetration postop and neurogenic ileus urinary retention myasthenia gravis reversal of NMJ blockade - postop

Question 28

postop reverse of NMJ blockade

Answer 28

neostigmine

Question 29

physostigmine

Answer 29

AChE inhibitor -cross BBB can be used for anticholinergic toxicity

Question 30

atropein OD tx

Answer 30

physostigmine

Question 31

pyridostigmine

Answer 31

AChE inhibitor -long acting for tx of MG

Question 32

adverse of cholinomimetics

Answer 32

exacerbate COPD, asthma, and peptic ulcers

Question 33

cholinesterase inhibitor poisoning

Answer 33

organophosphates -irreversible inhibition of AChE diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal m and CNS, lacrimation, sweating, salivation

Question 34

diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal m and CNS, lacrimation, sweating, salivation

Answer 34

cholinesterase inhibitor poisoning

Question 35

antidote for cholinesterase inhibitor poisoning

Answer 35

atropine - competitive inhibitor | pralidoxime - regenerate AChE

Question 36

pralidoxime

Answer 36

regenerate AChE

Question 37

atropine

Answer 37

muscarinic antagonist on eyes

Question 38

homoatropine

Answer 38

muscarinic antagonist on eyes

Question 39

tropicamide

Answer 39

muscarinic antagonist on eyes

Question 40

benztropine

Answer 40

muscarinic antagonist tx of PD

Question 41

glycopyrrolate

Answer 41

muscarinic antagonist preop - reduce airway secretion oral - tx of drooling and peptic ulcer

Question 42

hyoscyamine

Answer 42

muscarinic antagonist antispasmodic - irritable bowel syndrome

Question 43

dicyclomine

Answer 43

muscarinic antagonist antispasmodic - irritable bowel syndrome

Question 44

ipratropium

Answer 44

muscarinic antagonist COPD and asthma

Question 45

tiotropium

Answer 45

muscarinic antagonist COPD and asthma

Question 46

oxybutynin

Answer 46

muscarinic antagonist reduce bladder spasm and urge urinary incontinence (overactive bladder)

Question 47

solifenacin

Answer 47

muscarinic antagonist reduce bladder spasm and urge urinary incontinence (overactive bladder)

Question 48

tolterodin

Answer 48

muscarinic antagonist reduce bladder spasm and urge urinary incontinence (overactive bladder)

Question 49

scopolamine

Answer 49

muscarinic antagonist tx motion sickness - act in CNS