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Board Review - B - Pharmacology > Autonomic Drugs II > Flashcards

Autonomic Drugs II Flashcards

1
Q

hemicholinium MOA

A

block choline reuptake to cholinergic neurons

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2
Q

vesamicol MOA

A

block ACh uptake into storage vesicles in cholinergic neurons

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3
Q

botulinum MOA

A

block vesicular fusion of ACh vesicles with presynaptic membrane

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4
Q

AChE inhibitor MOA

A

block breakdown of ACh in synaptic cleft

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5
Q

metyrosine MOA

A

block tyrosine > DOPA

in noradrenergic nerve

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6
Q

reserpine MOA

A

block dopamine uptake into vesicles

in noradrenergic nerve

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7
Q

bretylium MOA

A

block NE release from noradrenergic nerves

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8
Q

guanethidine MOA

A

block NE release from noradrenergic nerves

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9
Q

amphetamine MOA

A

increase NE release from noradrenergic nerves

AND inhibit NE reuptake

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10
Q

ephedrine MOA

A

increased NE release from noradrenergic nerves

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11
Q

cocaine MOA

A

decreased reuptake of NE

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12
Q

TCA MOA

A

decreased reuptake of NE

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13
Q

NE negative feedback

A

to alpha2 on presynaptic autoreceptors

blocks release of more NE

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14
Q

AT2 receptor

A

activation leads to more NE release

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15
Q

bethanecol drug type

A

cholinomimetic

resistant to AChE

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16
Q

carbachol drug type

A

cholinomimetic

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17
Q

methacholine drug type

A

cholinomimetic

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18
Q

pilocarpine drug type

A

cholinomimetic

resistant to AChE

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19
Q

drug challenge test for asthma

A

methacholine

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20
Q

tx postop ileus, neurogenic ileus, urinary retention

A

bethanechol

21
Q

drug constrict pupil and relieve intraocular P in glaucoma

22
Q

drug stimulate seat, tears, saliva

tx open and closed angle glaucoma

A

pilocarpine

closed angle - pupillary sphincter
open angle - ciliary m of eye

23
Q

donepezil

A

AChE inhibitor

tx of AD

24
Q

galantamine

A

AChE inhibitor

tx of AD

25
Q

rivastigmine

A

AChE inhibitor

tx of AD

26
Q

edrophonium

A

AChE inhibitor

old diagnosis of myasthenia gravis - would improve sx

new test - anti-ACh receptor Ab

27
Q

neostigmine

A

AChE inhibitor
-no CNS penetration

postop and neurogenic ileus
urinary retention
myasthenia gravis
reversal of NMJ blockade - postop

28
Q

postop reverse of NMJ blockade

A

neostigmine

29
Q

physostigmine

A

AChE inhibitor
-cross BBB

can be used for anticholinergic toxicity

30
Q

atropein OD tx

A

physostigmine

31
Q

pyridostigmine

A

AChE inhibitor
-long acting
for tx of MG

32
Q

adverse of cholinomimetics

A

exacerbate COPD, asthma, and peptic ulcers

33
Q

cholinesterase inhibitor poisoning

A

organophosphates
-irreversible inhibition of AChE

diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal m and CNS, lacrimation, sweating, salivation

34
Q

diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal m and CNS, lacrimation, sweating, salivation

A

cholinesterase inhibitor poisoning

35
Q

antidote for cholinesterase inhibitor poisoning

A

atropine - competitive inhibitor

pralidoxime - regenerate AChE

36
Q

pralidoxime

A

regenerate AChE

37
Q

atropine

A

muscarinic antagonist

on eyes

38
Q

homoatropine

A

muscarinic antagonist

on eyes

39
Q

tropicamide

A

muscarinic antagonist

on eyes

40
Q

benztropine

A

muscarinic antagonist

tx of PD

41
Q

glycopyrrolate

A

muscarinic antagonist

preop - reduce airway secretion
oral - tx of drooling and peptic ulcer

42
Q

hyoscyamine

A

muscarinic antagonist

antispasmodic - irritable bowel syndrome

43
Q

dicyclomine

A

muscarinic antagonist

antispasmodic - irritable bowel syndrome

44
Q

ipratropium

A

muscarinic antagonist

COPD and asthma

45
Q

tiotropium

A

muscarinic antagonist

COPD and asthma

46
Q

oxybutynin

A

muscarinic antagonist

reduce bladder spasm and urge urinary incontinence (overactive bladder)

47
Q

solifenacin

A

muscarinic antagonist

reduce bladder spasm and urge urinary incontinence (overactive bladder)

48
Q

tolterodin

A

muscarinic antagonist

reduce bladder spasm and urge urinary incontinence (overactive bladder)

49
Q

scopolamine

A

muscarinic antagonist

tx motion sickness - act in CNS

Board Review - B - Pharmacology (7 decks)

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