Toxic epidermal necrolysis Flashcards
1
Q
What is toxic epidermal necrolysis?
A
A potentially life-threatening skin disorder that is commonly seen secondary to a drug reaction
2
Q
What are the features of toxic epidermal necrolysis?
A
Extensive rash
Scalded appearance
Systemically unwell
Positive Nikolsky’s sign
3
Q
What is Nikolsky’s sign?
A
A positive nikolsky sign is where a very thin top layer of skin is able to be sheared off
4
Q
What drugs are known to induce TEN?
A
Phenytoin
Sulphonamides
Allopurinol
Penicillins
Carbamazepine
NSAIDs
5
Q
What is the management of TEN?
A
Stop precipitating factor
Supportive care
IVIg
Immunosuppressive agents - ciclosporin and cyclophosphamide
Plasmapheresis
