Squamous cell carcinoma

Question 1

What is the pre-cancerous form of cutaneous SCC?

Answer 1

Actiinic keratosis

Question 2

What are the types of invasive cutaneous SCC?

Answer 2

Cutaneous horn - produced by excess keratin production

Marjolin ulcer - cutaneous SCC which develops within a scar or ulcer
Keratoacanthoma - rapidly developing keratinised nodule

Question 3

What are the risk factors for SCC?

Answer 3

Sun exposure
History of sunburn
Use of tanning beds
Chronic skin inflammation or injury
HPV infection
Immunosuppression

Question 4

What are the investigations used in the diagnosis of SCC?

Answer 4

Dermoscopy
Skin biopsy

Question 5

What are the clinical features of SCC?

Answer 5

Itchy, tender or painful lesions
Ulcerating lesions
Lesions on sun-exposed areas
- Ears, face, forearms, lower legs

Question 6

What are the signs of an SCC on examination?

Answer 6

Scaly or erythematous lesions
Crusted lesions
Bleeding lesions
Irregular borders

Question 7

What are the management options for SCC?

Answer 7

Surgical excision
Aggressive cryotherapy
Topical 5-fluorouracil
Imiquimod
Radiotherapy