TOX 7 - Benzene and phenol Flashcards
1
Q
Benzene
A
Widely used solvent
Good absorption in GI, vapour absorption in lungs
Concentrates in CNS, good lipid solubility
2
Q
Benzene acute intoxication
A
CNS depression (euphoria - nausea - locomotor problems)
no specific treatment
3
Q
Chronic benzene intoxication
A
Very serious toxicity of bone marrow
Causes all sorts of anemia
Neurological problems like insomnia and tremor
Possibly increases risk of leukemia
No specific treatment
4
Q
Phenol
A
acid compound, local anaesthetic effect -> severe local damage without pain
5
Q
Phenol intoxication - oral symptoms
A
Necrosis of mucous membrane in oral cavity and esophagus
6
Q
Phenol CNS toxicity
A
Stimulation - depression -> respiratory failure
7
Q
Phenol intoxication - late complication
A
Gastric lavage with cooking oil
Symptomatic treatment
