TOX 2 - Lead

Question 1

Blood effects

Answer 1

Heme production impaired -> hypochromic microcytic anemia

Question 2

Nervous system effects

Answer 2

Painless weakness of extensor muscles in hand

Encephalopathy

Cognitive abnormalities

Question 3

Kidney effect

Answer 3

Interstitial damage

Gout

Question 4

Reproductive

Answer 4

Decreased fertility in women

Question 5

GI

Answer 5

loss of apetite

constipation

pain

Question 6

Types of lead poisoning

Answer 6

Organic and inorganic lead poisoning

Question 7

Acute inorganic lead poisoning

Answer 7

Rare, industrial

GI and CNS symptoms

Question 8

Chronic inorganic lead poisoning

Answer 8

Common

Weakness, anorexia, anxiety, tremor, weight loss, headache, GI symptoms, extensor muscle weakness

Question 9

Inorganic lead poisoning

Answer 9

Caused by lead agent in gasoline

Causes acute CNS effects (headache, hallucinations)

Question 10

Treatment of lead poisoning

Answer 10

• termination of exposure

- chelation therapy (calcium disodium EDTA binds lead and enhances elimination)

Question 11

Chelation therapy

Answer 11

medical procedure that involves the administration of chelating agents to remove heavy metals from the body