TOX 11 - Cyanide Flashcards

1
Q

Source

A

CN releasing compounds like HCN gas

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2
Q

Absorption

A

All routes except skin

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3
Q

Mechanism

A

CN- binds to Fe+++ containing enzymes (cytochrome) -> blocks tissue oxidative process -> cytotoxic hypoxia

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4
Q

Symptoms

A

Anoxia of CNS and heart -> coma, respiratory arrest

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5
Q

Treatment

A
  1. NaNO2 administration: makes methaemoglobin that has iron with higher CN- affinity, thus restoring cytochrome enzymes
  2. Na2S2O3 administration: detoxify cyanomethaemoglobin
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