Tox Flashcards

1
Q

beta blocker OD that would cause seizure

A

propanolol

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2
Q

antidote to sarin gas most effective if given within 4-6 hours of exposure

A

pralidoxime

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3
Q

headache, blurry vision, papilledema, hair loss, pruritic skin, person overdosing on what?

A

Vitamin A

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4
Q

possible kerosene or hydrocarbon ingestion, pt asymptomatic, next step

A

obs 6 hours and do chest XR at 6 hours

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5
Q

valproic acid toxicity treatment

A

L carnitine

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6
Q

weird side effect of phenytoin

A

gingival hyperplasia

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7
Q

lead poisoning antidote

A

dimercaprol

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8
Q

eating fish, hot and cold sensation seem to be off - dx?

A

ciguatera tox

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9
Q

treatment of salicylate tox

A

sodium bicarb

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10
Q

retinal hyperemia - what ingestion and causes what acid build up?

A

methanol, formic acid build up

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11
Q

oxymetazoline/flonase OD can present as what other drug

A

clonidine

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12
Q

blurred vision, bradycardia, EKG with hyperK and peaked T waves - what toxicity

A

digoxin

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13
Q

patient develops HIT on heparin, next step

A

stop heparin and start direct thrombin inhibitor, bivalirudin

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14
Q

tx for cardiac arrest in digoxin overdose

A

10 vials of digoxin specific antibody

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15
Q

serious complication of lithium toxicity

A

arginine vasopressin resistance (nephrogenic DI)

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16
Q

what cofactor should be supplemented in ethylene glycol poisoning?

A

thiamine

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17
Q

what recreational drug can contribute to seratonin syndrome

A

MDMA/ectasy

18
Q

what blood lead level indicates the need for chelation therapy with dimercaprol in asymptomatic child?

19
Q

OD - pH 7.2, PaCO2 at 20, HCO3 at 12

A

salicylate tox

20
Q

what acid base disturbance do you see first in salicylate tox

A

early respiratory alkalosis

21
Q

what is the active metabolite in acetaminophen toxicity

A

N-acetyl-p-benzoquinoneimine (NAPQI)

22
Q

ketosis without a wide anion gap metabolic acidosis

A

isopropyl alcohol (rubbing alcohol)

23
Q

30 min after TCA overdose, sinus tach, next treatment

A

activated charcoal

24
Q

treatment of SLUDGE and DUMBBELLS

A

atropine, then pralidoxime (2 PAM)

25
what is contraindicated in hydrocarbon toxicity
amiodarone
26
physostigmine side effect?
profound bradycardia, seizures, asystole
27
drug often with eliquis that can cause increased plasma concentration of eliquis
diltizem
28
hypernatremia and lithium toxicity, treatment/
hemodialysis - nephrogenic DI
29
ingestion, + ketones, elevated Cr, but normal BUN, no AGAP
isopropyl alcohol
30
2-8 weeks after iron overdose, what dx?
bowel obstruction, pyloric stenosis
31
what reverses dabigatran (direct thrombin inhibitor)
Idarucizumab (monoclonal antibody fragment)
32
high anion gap acidosis without lactic or ketone elevation, ingested what?
ethylene glycol
33
accidental hydrocarbon ingestion, next step
obs 6 hours and repeat chest XR
34
finding in chronic digoxin overdose
color vision changes
35
treatment for silo fillers disease
methylene blue, nitrogen has displaced
36
TCAs act by ...
fast inward Na channel blockade (class I antidysrrhythmics as well)
37
carbon monoxide toxicity causes a ... shift of the oxygen-hemoglobin dissociation curve
left shift
38
bidirectional v tach
digoxin toxicity
39
mechanism of action of NAC
Regenerates sulfhydryl donor glutathione
40
methylene chloride will cause
carboxyhemoglobin
41
vomiting and diarrhea after fish, paresthesias and teeth feel loose
ciguatera poisoning