Tox Flashcards
beta blocker OD that would cause seizure
propanolol
antidote to sarin gas most effective if given within 4-6 hours of exposure
pralidoxime
headache, blurry vision, papilledema, hair loss, pruritic skin, person overdosing on what?
Vitamin A
possible kerosene or hydrocarbon ingestion, pt asymptomatic, next step
obs 6 hours and do chest XR at 6 hours
valproic acid toxicity treatment
L carnitine
weird side effect of phenytoin
gingival hyperplasia
lead poisoning antidote
dimercaprol
eating fish, hot and cold sensation seem to be off - dx?
ciguatera tox
treatment of salicylate tox
sodium bicarb
retinal hyperemia - what ingestion and causes what acid build up?
methanol, formic acid build up
oxymetazoline/flonase OD can present as what other drug
clonidine
blurred vision, bradycardia, EKG with hyperK and peaked T waves - what toxicity
digoxin
patient develops HIT on heparin, next step
stop heparin and start direct thrombin inhibitor, bivalirudin
tx for cardiac arrest in digoxin overdose
10 vials of digoxin specific antibody
serious complication of lithium toxicity
arginine vasopressin resistance (nephrogenic DI)
what cofactor should be supplemented in ethylene glycol poisoning?
thiamine
what recreational drug can contribute to seratonin syndrome
MDMA/ectasy
what blood lead level indicates the need for chelation therapy with dimercaprol in asymptomatic child?
70 ug/dL
OD - pH 7.2, PaCO2 at 20, HCO3 at 12
salicylate tox
what acid base disturbance do you see first in salicylate tox
early respiratory alkalosis
what is the active metabolite in acetaminophen toxicity
N-acetyl-p-benzoquinoneimine (NAPQI)
ketosis without a wide anion gap metabolic acidosis
isopropyl alcohol (rubbing alcohol)
30 min after TCA overdose, sinus tach, next treatment
activated charcoal
treatment of SLUDGE and DUMBBELLS
atropine, then pralidoxime (2 PAM)
what is contraindicated in hydrocarbon toxicity
amiodarone
physostigmine side effect?
profound bradycardia, seizures, asystole
drug often with eliquis that can cause increased plasma concentration of eliquis
diltizem
hypernatremia and lithium toxicity, treatment/
hemodialysis - nephrogenic DI
ingestion, + ketones, elevated Cr, but normal BUN, no AGAP
isopropyl alcohol
2-8 weeks after iron overdose, what dx?
bowel obstruction, pyloric stenosis
what reverses dabigatran (direct thrombin inhibitor)
Idarucizumab (monoclonal antibody fragment)
high anion gap acidosis without lactic or ketone elevation, ingested what?
ethylene glycol
accidental hydrocarbon ingestion, next step
obs 6 hours and repeat chest XR
finding in chronic digoxin overdose
color vision changes
treatment for silo fillers disease
methylene blue, nitrogen has displaced
TCAs act by …
fast inward Na channel blockade (class I antidysrrhythmics as well)
carbon monoxide toxicity causes a … shift of the oxygen-hemoglobin dissociation curve
left shift
bidirectional v tach
digoxin toxicity
mechanism of action of NAC
Regenerates sulfhydryl donor glutathione
methylene chloride will cause
carboxyhemoglobin
vomiting and diarrhea after fish, paresthesias and teeth feel loose
ciguatera poisoning
