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..EM Board Review > heme/immuno > Flashcards

heme/immuno Flashcards

1
Q

Activated protein C resistance is caused by

A

factor V Leiden mutation, the most commonly inherited hypercoagulable disorder.

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2
Q

cancer pt, why are they hypercalcemic

A

release of PTHrp from tumor

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3
Q

anaphylactic transfusion reaction can be caused by

A

IgA deficiency

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4
Q

fever, microangiopathic hemolytic anemia, thrombocytopenia, renal dysfunction, and neurologic changes.

A

TTP

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5
Q

TTP treatment

A

plasma exchange

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6
Q

ER tx of tumor lysis syndrome

A

IV fluids

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7
Q

tx acute rheumatic fever with severe penicillin allergy

A

clinda

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8
Q

decrease febrile nonhemolytic transfusion reaction by

A

use leukocyte reduced packed red blood cells

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9
Q

highest risk of hyperleukocytosis cancer process

A

AML

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10
Q

new medication causing anemia

A

type II hypersensitivity reaction, autoimmune hemolytic anemia

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11
Q

most highly associated symptom with positive biopsy for temporal arteritis

A

jaw claudication

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12
Q

lip swelling and belly pain

A

hereditary angioedema

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13
Q

which hypersensitivity and examples - IgG or IgM antibodies react with cell antigens with resultant complement activation

A

type II cytotoxic- autoimmune hemolytic anemia, erythroblastosis fetalis, goodpasture (requires two separate exposures)

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14
Q

which hypersensitivity and examples - IgG or IgM immune complex deposition and subsequent complement activation

A

type III immune complex - serum sickness, SLE, PSGN

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15
Q

activated T cells against cell surface bound antigens

A

type IV hypersensitivity - contact dermatitis, TB skin test, transplant rejection

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16
Q

rituximab can cause what kind of hypersensitivy reaction

A

type III, serum sickness

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17
Q

INR and PTT in TTP

A

will be normal. no coagulopathy

18
Q

RA, neutropenia, and splenomegaly

A

felty syndrome

19
Q

adopted girl with low MCV anemia

A

thalassemia

20
Q

low retic count in sickle cell patient, infection of

A

parvovirus

21
Q

refractory anaphylaxis on a beta blocker, give

A

glucagon

22
Q

getting a transfusion and develops fever, headache, joint pain, wheezing, hypotension

A

acute hyemolytic transfusion reaction

23
Q

venous engorgement with boxcar segments

A

hyperviscosity syndrome causing retinal ischemia

24
Q

factor VIII not available for hemophilia pt, give

A

cryoprecipitate

25
Q

reverse warfarin with

A

4 factor PCC ( has II, VII, IX, and X)

26
Q

MC lab abnormality in DIC

A

thrombocytopenia

27
Q

check what labs in HSP

A

UA, Cr?

28
Q

CML pt, with WBCs >100, anemia, thrombocytopenia (no symptoms of leukostasis), tx

A

urgent chemo induction, abx, hydroxyurea

29
Q

why does cirrhotic patient have low platelets

A

splenic sequestration

30
Q

acute chest syndrome but vitals normalize on NC oxygen, treatment?

A

abx and simple transfusion

31
Q

microcytic anemia, no bleeding, normal iron studies

A

thalassemia

32
Q

anemia of TTP is

A

MAHA

33
Q

ED tx of diffuse alveolar hemorrhage in setting of GPA/Wegners

A

steroids and immunotherapy

34
Q

tx of hereditary angioedema

A

C1- Inhibitor, then FFP

35
Q

macrocytic anemia, neutropenia, retic <1%

A

aplastic anemia

36
Q

getting a blood transfusion, reaction occurs including red urine. dx and tx

A

hemolytic transfusion reaction, supportive and replace tubing

37
Q

the setting of cyanide toxicity, amyl nitrite and sodium nitrite work by inducing

A

methhemoglobinemia

38
Q

first line tx for autoimmune hemolytic anemia

A

steroids

39
Q

positive Coombs test

A

hemolytic transfusion reaction (antibody complex detected)

40
Q

blood type of mom to cause hemolytic disease of the newborn

A

type O, Rh negative

..EM Board Review (15 decks)

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