heme/immuno

Question 1

Activated protein C resistance is caused by

Answer 1

factor V Leiden mutation, the most commonly inherited hypercoagulable disorder.

Question 2

cancer pt, why are they hypercalcemic

Answer 2

release of PTHrp from tumor

Question 3

anaphylactic transfusion reaction can be caused by

Answer 3

IgA deficiency

Question 4

fever, microangiopathic hemolytic anemia, thrombocytopenia, renal dysfunction, and neurologic changes.

Answer 4

TTP

Question 5

TTP treatment

Answer 5

plasma exchange

Question 6

ER tx of tumor lysis syndrome

Answer 6

IV fluids

Question 7

tx acute rheumatic fever with severe penicillin allergy

Answer 7

clinda

Question 8

decrease febrile nonhemolytic transfusion reaction by

Answer 8

use leukocyte reduced packed red blood cells

Question 9

highest risk of hyperleukocytosis cancer process

Answer 9

AML

Question 10

new medication causing anemia

Answer 10

type II hypersensitivity reaction, autoimmune hemolytic anemia

Question 11

most highly associated symptom with positive biopsy for temporal arteritis

Answer 11

jaw claudication

Question 12

lip swelling and belly pain

Answer 12

hereditary angioedema

Question 13

which hypersensitivity and examples - IgG or IgM antibodies react with cell antigens with resultant complement activation

Answer 13

type II cytotoxic- autoimmune hemolytic anemia, erythroblastosis fetalis, goodpasture (requires two separate exposures)

Question 14

which hypersensitivity and examples - IgG or IgM immune complex deposition and subsequent complement activation

Answer 14

type III immune complex - serum sickness, SLE, PSGN

Question 15

activated T cells against cell surface bound antigens

Answer 15

type IV hypersensitivity - contact dermatitis, TB skin test, transplant rejection

Question 16

rituximab can cause what kind of hypersensitivy reaction

Answer 16

type III, serum sickness

Question 17

INR and PTT in TTP

Answer 17

will be normal. no coagulopathy

Question 18

RA, neutropenia, and splenomegaly

Answer 18

felty syndrome

Question 19

adopted girl with low MCV anemia

Answer 19

thalassemia

Question 20

low retic count in sickle cell patient, infection of

Answer 20

parvovirus

Question 21

refractory anaphylaxis on a beta blocker, give

Answer 21

glucagon

Question 22

getting a transfusion and develops fever, headache, joint pain, wheezing, hypotension

Answer 22

acute hyemolytic transfusion reaction

Question 23

venous engorgement with boxcar segments

Answer 23

hyperviscosity syndrome causing retinal ischemia

Question 24

factor VIII not available for hemophilia pt, give

Answer 24

cryoprecipitate

Question 25

reverse warfarin with

Answer 25

4 factor PCC ( has II, VII, IX, and X)

Question 26

MC lab abnormality in DIC

Answer 26

thrombocytopenia

Question 27

check what labs in HSP

Answer 27

UA, Cr?

Question 28

CML pt, with WBCs >100, anemia, thrombocytopenia (no symptoms of leukostasis), tx

Answer 28

urgent chemo induction, abx, hydroxyurea

Question 29

why does cirrhotic patient have low platelets

Answer 29

splenic sequestration

Question 30

acute chest syndrome but vitals normalize on NC oxygen, treatment?

Answer 30

abx and simple transfusion

Question 31

microcytic anemia, no bleeding, normal iron studies

Answer 31

thalassemia

Question 32

anemia of TTP is

Answer 32

MAHA

Question 33

ED tx of diffuse alveolar hemorrhage in setting of GPA/Wegners

Answer 33

steroids and immunotherapy

Question 34

tx of hereditary angioedema

Answer 34

C1- Inhibitor, then FFP

Question 35

macrocytic anemia, neutropenia, retic <1%

Answer 35

aplastic anemia

Question 36

getting a blood transfusion, reaction occurs including red urine. dx and tx

Answer 36

hemolytic transfusion reaction, supportive and replace tubing

Question 37

the setting of cyanide toxicity, amyl nitrite and sodium nitrite work by inducing

Answer 37

methhemoglobinemia

Question 38

first line tx for autoimmune hemolytic anemia

Answer 38

steroids

Question 39

positive Coombs test

Answer 39

hemolytic transfusion reaction (antibody complex detected)

Question 40

blood type of mom to cause hemolytic disease of the newborn

Answer 40

type O, Rh negative