Tough ones Flashcards
Where does Q get it’s ammonium from?
NH4
What is the role of ALT in starvation?
Takes pyruvate generated in muscles and converts it to alanine for transport to the liver
N (when produced from Q) gets it NH4 from where?
From Q
What is the enzyme that catalyzes the reaction of glycine to serine?
Serine-hydroxymethyl transferase
What is the most oxidized form of THF?
N10
What is the most reduced form of THF?
N5
What are the molecule that donate to the one carbon pool?
Formaldehyde, formate, S, G, H
What is the cause and symptoms of Homocystieneuria?
Defect in Cystathinoine beta synthase
Lens dislocation, MR, thromboembolism
What are the symptoms of PKU? Treatment?
MR, SZs, rash
Low F and Y diet
Which amino acids serve as carbon donors in the blood?
A and Q
HHF6 lowers the activity of what other enzyme? What is this involved in?
N-acetyl glutaminase, which lower the N-acetyl Q production an the urea cycle.
A defect in the glycine cleavage system will result in what condition?
Glycine encephalopathy
Biotin is needed for what reaction?
Propionyl-coa to d-methylmalonyl-coa via propionyl coa decarboxylase
There are only two reactions in the body that require B12. Which are they?
Propionyl to succinyl-coa reaction
Homocystine to methionine reaction
The ONLY reaction in the body that can oxidize N5-methyl THF is what reaction? What variant of THF is produced in the process?
THF
What is the chemical responsible for he discoloration of alkaptonuria?
Benzoquinone
Tyrosenemia I is the result of a defect in fumarylacetoacetate hydrolase. What is produced INSTEAD of fumarate and acetate?
Succinyl acetone
Which amino acids can undergo deamination without an aminotransferase?
THCS
In the intestinal renal axis, what amino acid is picked up? What is it then converted to?
Q, then citrulline, then R
There are two compounds given to someone with urea cycle issues. Name them, and the amino acids they reaction with.
Phenyl-butryrate reactions with glutamine
Benzoate reacts with glycine
Name the enzyme that produces GABA from E, and Histamine from H
Pryidoxal phosphate
FA oxidation/ketone synthesis increases transcription for related enzymes through what system?
PPRE
Gluconeogenesis stimulate transription of enzymes through what?
CRE
Insulin induces transcription of lipid synthesis enzymes via what?
SRE
Insulin represses transcription of gluconeogenesis enzymes via what?
IRE
The enzyme IDO converts what to what in which pathway?
W to N-formylynurine in the synthesis of niacin
How does the enzyme IDO contribute to cancer?
Excess activity leads to the blocking of T cell action on cancer cells
A defect in carbomoyl synthetase I leads to what condition?
Hyperammonemia
A defect in Ornathine transcarbamoylase leads to what condition?
Hyperammonemia
A defect in arginosuccinate synthetase leads to what condition?
Citrullinemia
A defect in Arginosuccinate lyase leads to what condition?
Arginosuccinate acid uria
A defect in Arginase leads to what condition?
Hyperarginemia