Special products Flashcards
Parkinson’s disease is the result of alpha synuclean being incorporated into dopagenic neurons. What is the chemical discussed in class that can relieve symptoms of parkinson’s?
DOPA
What is the enzyme responsible for synthesis of DIT and MIT in the T3/T4 pathway?
Peroxidase
What is the protein called that stores Y residues
Thyroglobulin
Melanin is the result of what initial enzyme reaction
Tyrosinase conveting Y into DOPA, then to Dopaquinone.
Oculocutaneous albinism type I is the result in a defect in what enzyme? What the symptoms and complications?
Tyrosinase
Lack of pigmentatiion
skin tumors, eye issues
Serotonin is made from which amino acid?
W
What is the enzyme that convert W to 5-hydroxytryptophan?
tryptophan hydroxylase
Niacin synthesis begins with what enzyme acting on what amino acid?
IDO on W
What does IDO generate? What role does IDO play in cancer?
N-formylkynureine.
Ido produces metabolites that inhibit the synthesis of T-cells
What is the enzyme that catalyzes histadine to histamine?
Pyridoxal phosphate
What is the enzyme that catalyzes E to GABA?
Pyridoxal phosphate
Glutathionine is made from which three amino acids?
E-C-G with a gamma glutamyl linkage
What role does glutathionine play?
Protects RBCs from oxidation by being oxidized to GSSG.
What enzyme catalyzes the reduction of GSSG to glutathionine? What high energy molecule is needed? (NADH, NADPH, FADH, or ATP?)
Glutathione reductase
NADPH
What enzyme catalyzes the oxidation of glutathione?
Glutathione peroxidase.
