Total parenteral nutrition in practice Flashcards

1
Q

What is enteral nutrition?

A

nutrition delivered into the gut by a tube when nutrition can’t be taken normally by the mouth but the gut is working

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2
Q

reasons for enteral nutrition

A
  • stroke/neurological conditions where swallowing impaired
  • after operation on face/neck/throat/gullet/stomach
  • blockages of guller/stomach
  • after radiotherapy to gullet/stomach
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3
Q

What is used first for enteral nutrition?

A

feeding tubes placed through the nostril, down oesophagus (gullet) and lie in the stomach or small bowel (jejunum - NJ tubes)

-> nasogastric tube

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4
Q

What is used if patient’s ability to eat won’t recover quickly/at all?

A

feeding tube placed through abdominal wall directly into stomach

-> gastrostomy - PEG

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5
Q

What route is PN given?

A

IV

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6
Q

Composition of PN solution

A

carbohydrates 60-70%

fat 30-40%

protein 1g or 30-40kcal from non-protein sources

electrolytes, minerals, vitamins, trace elements

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7
Q

What med classification is PN?

A

POM

-> needs to be on Rx

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8
Q

indications for PN

A
  • BMI < 18.5
  • unintentional weight loss > 10% within 3-6mths
  • BMI < 20 and unintentional weight loss > 5% within last 3-6mths
  • eaten little/nothing for > 5 days and likely for next 5+
  • poor absorptive capacity and/or high nutrient losses and/or increased nutritional needs from catabolism
  • inadequate/unsafe oral/enteral nutritional intake
  • non-functional/leaking GIT
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9
Q

What is the nutritional Rx for people NOT severly ill/injured/risk of feeding syndrome?

A
  • 25-35 kcal/kg/day (total energy)
  • 0.8-1.5g protein/kg/day
  • 30-35 ml fluid/kg (allow for losses and other IV inputs)
  • adequate electrolytes, minerals, micronutrients, fibre
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10
Q

How to start PN in an adult?

A
  • start with no more than 50% of estimated target energy and protein need
  • built up to meet needs over 24-48hrs
  • full requirements of fluid, electrolytes, vits, from start
  • eaten little/nothing past 5 days, introduce no more than 50% for first days
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11
Q

When is PN indicated for children?

A
  • prematrurity
  • GIT abnormalities
  • low birth weight infants
  • major surgery
  • IBD
  • respiratory disorders (cystic fibrosis)
  • sepsis
  • burns (dehydration)
  • major traums
  • mucositis and malabsorption (chemotherapy)
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12
Q

What can energy loss be from in children?

A

ostomies
malabsorption
diarrhiea
infection

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13
Q

energy requirements for children

A

pre-term - 110-120kcal/kg/day

0-1 yrs - 90-100 kcal/kg/day

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14
Q

What formula calculates fluid requirements for children?

A

Holliday-Segar formula

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15
Q

What fluid requirements are needed for children? (Holliday-Segar formula)

A
  • 100 ml/kg/day for 1st 10kg of weight
  • 50 ml/kg/day for next 10kg
  • 20 ml/kg/day for weight over 20kg
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16
Q

What is the max fluid that male/female children need?

A

over 24hrs

  • males no more than 2500ml
  • females no more than 2000ml
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17
Q

What vol of fluid does 16kg child need in 24hrs?

A

10 x 100
6 x 50
= 1300ml

18
Q

What rate per hour needed for 1300ml for 16kg child?

A

1300 / 24
= 54.17

-> 54 or 55 ml/hr

19
Q

How much fluid for 125kg child over 24hrs?

A

10 x 100
10x x 50
105 x 20
= 3600ml

-> males 2500ml, females 200ml, so might not need this much

20
Q

How is PN administered?

A

peripheral IV catheter - cannula in arm

central IV catheter - central line into heart

21
Q

max glucose conc and osmolarity for peripharal PN

A

max glucose conc of 10%

max osmolarity 1210 mosmol/kg

22
Q

max glucose conc for central PN

A

can give high glucose concs

-> usually below 25% (18%)

23
Q

When should PN be stopped?

A

when patient is established on oral/enteral support

24
Q

2 types of monitoring for PN

A

physical

metabolic complications

25
physical monitoring for PN
- body weight - length/height - head circumference -> plotted on growth charts, same scales used, undressed
26
metabolic complications monitoring
short term - re-feeding syndrome - hyperglycaemia - hypoglycaemia - hypertriglyceridemia - mineral/electrolyte imbalances -> close monitoring in first week
27
What is re-feeding syndrome?
reduction in basal metabolic rate during times of semi-starvation rapid change in metabolic status when feeding re-introduced -> can have life-threatening complications
28
How to re-introduce calories?
slowly - 50% day 1 - 75% day 2 - 100% day 3 -> may need to be slower, daily bloods essential
29
What mineral has an increased requirement when re-introducing calories?
phosphate - when body switching back to carb metabolism - P depeltion in starvation
30
What patients are at risk of re-feeding?
1 of these: - BMI < 16 - unintentional weight loss > 15% in last 3-6mths - little/no nutritional intake for > 10 days - low potassium/phosphate/magnesium levels before feeding 2+ of these risk factors: - BMI < 18.5 - unintentional weight loss >10% 3-6mths - no intake > 5 days - Hx alcohol abuse/drugs (insulin, chemo, antacids, diuretics)
31
What nutrition is given for those at risk of re-feeding?
- start at max 10 kcal/kg/day - inc slowly by 4-7 days - 5 kcal/kg/day in extreme cases - respore cirsulatory vol/monitor fluid balance
32
What additional things given for risk of re-feeding before PN and for first 10 days?
- oral thiamine 200-300 mg daily - Vit B co strong 1 or 2 tabs TDS (or full dose IV Vit B) - balanced multivitamin/trace element supplement OD
33
What supplements need to be given for oral/enteral/IV?
potassium phosphate magnesium
34
What needs to be monitored?
- lipids and triglycerides - trace elements and vitamin deficiencies - hepatic dysfunction
35
Why monitor lipids and triglycerides?
levels needed to determine patient's oxidative capacity for lipid metabolism
36
Why monitor tracelements and vitamin deficiencies?
deficiencies can occur in patients on LT PN don't need routiene monitoring unless pt fed > 1 mth not an issue when pt on established PN feeding
37
Why monitor hepatic dysfunction?
- allow early detection of liver adverse effects | - cholestasis is a complication
38
complications of PN
infection - catheter related spesis, systemic infection metabolic - glucose intolerance, electrolyte disturbances, acidosis, cholestasis administration - line access, compatibility information
39
compatibility with PN
don't mix PN/lipid with any other meds -> nothing down the same lumen
40
Why is enteral nutrition preferred over parenteral nutrition? (working gut)
- more physiological (working gut) - simpler (no IV) - cheaper - less complicated -> might need both