Topoisomerase and Spindle Inhibitors Toxicities

Question 1

Vincristine (unusual toxicities)

Answer 1

Cumulative Neurotoxicity

SIADH (syndrome of inappropriate ADH secretion) due to pituitary toxicity (volume retention)

Question 2

Vinblastine (unusual toxicities)

Answer 2

Leucopenia, Lesser Peripheral Neurotoxicity

Question 3

Irinotecan/Topotecan (unusual toxicities)

Answer 3

• GI Toxicity
• Avoid in Gilbert Syndrome
• AchE Inhibition (causes asthenia)

Question 4

Paclitaxel (unusual toxicities)

Answer 4

Peripheral Neuropathy

Question 5

Docataxel (unusual toxicities)

Answer 5

Edema-Fluid Retention

Peripheral Neuropathy

Question 6

Anthracyclines (unusual toxicities)

Answer 6

Cardiotoxicity (acute and chronic effects)

Question 7

Bleomycin (unusual toxicities)

Answer 7

Pulmonary Fibrosis

Question 8

Asparaginase (unusual toxicities)

Answer 8

Pancreatitis